Featured Research

from universities, journals, and other organizations

Research Points To Potential Chink In Cancer's Armor

Date:
October 6, 2009
Source:
University of York
Summary:
Scientists in the UK have successfully silenced the JNK2 gene that appears essential to cancer cell survival. The researchers used a process called RNA interference to target the JNK2 gene in both cancer and healthy cells. The cancer cells died but the healthy cells were unaffected.

Scientists at the University of York have identified and successfully silenced a gene that appears essential to cancer cell survival.

Professor Jo Milner and Dr Shafiq Ahmed, from the YCR P53 Research Unit in the Department of Biology, used a process called RNA interference to target the JNK2 gene in both cancer and healthy cells. The cancer cells died but the healthy cells were unaffected.

This discovery suggests that the survival of cancer cells depends upon certain genes which healthy cells can survive without, an important step towards the development of the next generation of cancer treatments.

Dr Ahmed said: "Our results indicate that one day it may be possible to treat cancer without the harmful side-effects so often associated with today's treatments. Our study has identified a cancer-specific target which could be selectively inhibited using small-molecules, or other means, without the use of radiotherapy and chemotherapy."

This laboratory-based work is still at a very early stage and the next step is to test a larger range of different cancer cell types and also to test normal healthy cells from different tissues.

The research, which examined colorectal cancer and breast cancer cell lines among others, was funded by Yorkshire Cancer Research and is published in the journal PLoS ONE.

A major aim of Professor Milner's research team is to identify cancer-specific survival genes and to ask if such genes offer a new route for cancer treatment. This field of research has been made possible through the development of RNA interference which allows the silencing of a single gene amongst thousands of genes.

Professor Milner said: "Our approach is now revealing unexpected properties for certain genes including JNK2. We have also studied JNK2's close relative, JNK1, and found that these two genes seem to oppose each other. JNK1 and JNK2 resemble the ‘Jekyll and Hyde' for cancer cell survival."

"A further surprise is that the mechanism by which these two genes function under normal every-day conditions appears distinct from the mechanism which is activated by current anti-cancer therapies."

Dr Kathryn Scott, from Yorkshire Cancer Research, said: "The work of Professor Milner and Dr Ahmed represents another example of the world-class research that Yorkshire Cancer Research funds throughout the region."


Story Source:

The above story is based on materials provided by University of York. Note: Materials may be edited for content and length.


Cite This Page:

University of York. "Research Points To Potential Chink In Cancer's Armor." ScienceDaily. ScienceDaily, 6 October 2009. <www.sciencedaily.com/releases/2009/10/091005210009.htm>.
University of York. (2009, October 6). Research Points To Potential Chink In Cancer's Armor. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2009/10/091005210009.htm
University of York. "Research Points To Potential Chink In Cancer's Armor." ScienceDaily. www.sciencedaily.com/releases/2009/10/091005210009.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com
What's To Blame For Worst Ebola Outbreak In History?

What's To Blame For Worst Ebola Outbreak In History?

Newsy (July 27, 2014) A U.S. doctor has tested positive for the deadly Ebola virus, as the worst-ever outbreak continues to grow. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins