Featured Research

from universities, journals, and other organizations

Rare Head And Neck Cancer Linked To HPV, Study Finds

Date:
October 9, 2009
Source:
University of Michigan Health System
Summary:
An increase in cases of a rare type of head and neck cancer appears to be linked to HPV, or human papillomavirus, according to a new study.

An increase in cases of a rare type of head and neck cancer appears to be linked to HPV, or human papillomavirus, according to a new study from researchers at the University of Michigan Comprehensive Cancer Center.

Related Articles


The study looked at patients with nasopharyngeal cancer, a tumor that grows behind the nose and at the top of the throat, above the tonsils. This rare cancer occurs in less than 1 of every 100,000 Americans.

“Though rare, this is the first report of nasopharyngeal cancer being caused by the HPV epidemic. We are in the middle of a tonsil cancer epidemic, seeing many patients with tonsil cancer linked to HPV. It turns out that HPV may also be a new cause of this rare form of cancer that occurs in this hidden location,” says study author Carol Bradford, M.D., professor and chair of otolaryngology at the U-M Medical School.

In the study, which appears online in the journal Head & Neck, the researchers looked at tissue samples taken before treatment for either nasopharyngeal cancer or tonsil cancer. Of the 89 patients in the study, five had nasopharyngeal cancer, and four of those were positive for HPV.

At the same time, the four HPV-positive tumors were also all negative for Epstein-Barr virus, which has previously been one of the biggest infectious causes of nasopharyngeal cancer.

“Since I began studying head and neck cancer, I have wondered what the cause of Epstein-Barr virus-negative nasopharyngeal tumors might be. This research suggests that there is a changing etiology for nasopharyngeal cancer in the North American population that may mirror the HPV-positive epidemic of tonsil cancer,” says study author Thomas Carey, Ph.D., professor of otolaryngology and pharmacology and co-director of the head and neck oncology program at the U-M Comprehensive Cancer Center.

Overall, about 60 percent of nasopharyngeal cancer patients are alive five years after treatment. In fact, death rates for this type of cancer have declined 4 percent per year. The researchers suspect one potential reason is that HPV-related tumors are more responsive to chemotherapy or radiation than tumors linked to the Epstein-Barr virus.

Because nasopharyngeal cancer is so rare, the authors propose a multi-center trial to recruit more patients to verify the role of HPV in nasopharyngeal cancer.

Additional authors: Jessica Maxwell, M.D., M.P.H.; Bhavna Kumar, M.S.; Felix Feng, M.D.; Jonathan McHugh, M.D.; Kitrina Cordell, M.D.; Avraham Eisbruch, M.D.; Francis Worden, M.D.; Gregory Wolf, M.D.; Mark Prince, M.D.; Jeffrey Moyer, M.D.; Theodoros Teknos, M.D.; and Douglas Chepeha, M.D., all from U-M; Jay Stoerker, Ph.D. and Heather Walline, M.A., from SensiGen LLC

Funding: National Institutes of Health, National Cancer Institute, U-M Head and Neck Cancer SPORE grant, state of Michigan loan to SensiGen LLC

Disclosure: SensiGen is a wholly-owned subsidiary of Sequenom. The University of Michigan's Office of Technology Transfer has exclusively licensed HPV detection technology to Sequenom.

Reference: Head & Neck, published online Sept. 15, 2009, DOI:10.1002/hed.21216


Story Source:

The above story is based on materials provided by University of Michigan Health System. Note: Materials may be edited for content and length.


Cite This Page:

University of Michigan Health System. "Rare Head And Neck Cancer Linked To HPV, Study Finds." ScienceDaily. ScienceDaily, 9 October 2009. <www.sciencedaily.com/releases/2009/10/091007103036.htm>.
University of Michigan Health System. (2009, October 9). Rare Head And Neck Cancer Linked To HPV, Study Finds. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2009/10/091007103036.htm
University of Michigan Health System. "Rare Head And Neck Cancer Linked To HPV, Study Finds." ScienceDaily. www.sciencedaily.com/releases/2009/10/091007103036.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins