Featured Research

from universities, journals, and other organizations

Genes Signal Late-stage Laryngeal Cancer, Poorer Outcome

Date:
October 8, 2009
Source:
Henry Ford Health System
Summary:
Researchers have identified tumor-suppressing genes that may provide a more accurate diagnosis of disease stage and survival for laryngeal cancer patients than current standards. The study finds genetic abnormalities of the ESR1 gene and the HIC1 gene are predictors of late-stage laryngeal cancer and shorter survival, respectively, for patients with the disease.

Researchers at Henry Ford Hospital have identified tumor-suppressing genes that may provide a more accurate diagnosis of disease stage and survival for laryngeal cancer patients than current standards.

The study finds genetic abnormalities of the ESR1(estrogen specific receptor 1) gene and the HIC1 (hypermethylated in cancer 1) gene are predictors of late-stage laryngeal cancer and shorter survival, respectively, for patients with the disease.

Study results will be presented Wednesday, Oct. 7 at the American Academy of Otolaryngology–Head & Neck Surgery Foundation Annual Meeting & OTO EXPO.

"These two genes provide some insight into the biology of the tumor," says study senior author Maria J. Worsham, Ph.D., director of research in the Department of Otolaryngology at Henry Ford Hospital. "Loss of gene function as a result of abnormal methylation of promoter regions of tumor suppressor genes can be reversed by drugs that can restore normal gene function, opening the door to other treatment options for patients with laryngeal cancer."

Similar to previous studies on laryngeal cancer, the Henry Ford study also shows that African Americans are more likely to be diagnosed with late-stage laryngeal cancer.

This year alone, the American Cancer Society estimates 12,290 new cases of laryngeal cancer – cancers that start in the voice box – will be diagnosed.

Following diagnosis, the cancer stage is currently assessed based on tumor size and how far it's spread within the voice box, and whether the cancer has spread to lymph nodes or other organs. The stage (0-4) of the cancer helps health care providers make a prognosis for survival and determine a possible course for treatment.

For the study, Henry Ford researcher and lead author Josena Stephen, M.D., and Dr. Worsham looked at 80 patients with laryngeal squamous cell cancer who were diagnosed between 1996 and 2008. Forty percent of the study group was African American.

Using tissue DNA samples the researchers examined the methylation status of 24 tumor suppressor genes and tested for the presence of the human papilloma virus (HPV). DNA methylation – a type of chemical modification of DNA where a methyl group (CH3) can be added (hypermethylation) or removed (hypomethylation) – allows the researchers to look for genetic abnormalities within tumor samples.

The study found:

  • Abnormal DNA methylation of ESR1 predicted late stage disease.
  • African Americans are more likely to have advanced stage disease than their Caucasian counterparts, a finding consistent with previous research.
  • Abnormal DNA methylation of HIC1, late stage disease, and vascular invasion were predictors of shorter survival.
  • The median survival for patients in the study group was 4.2 years.
  • HPV was much higher in this group of patients (37 percent), supporting the role of HPV in laryngeal cancer.
  • The majority of patients were either current or past smokers and alcohol users, again confirming the role these factors play in laryngeal cancer.

"When this research crosses from the lab to clinical care, the contribution of specific gene changes will assist in improving the accuracy of cancer staging and length of survival for laryngeal cancer patients," explains Dr. Worsham.

"So if a patient comes in with stage 1, based on current standards, and then we find methylation of ESR1, the patient may have underpinnings of a more aggressive tumor with characteristics that are more in line with a stage 3 or stage 4 diagnosis, refining treatment options."


Story Source:

The above story is based on materials provided by Henry Ford Health System. Note: Materials may be edited for content and length.


Cite This Page:

Henry Ford Health System. "Genes Signal Late-stage Laryngeal Cancer, Poorer Outcome." ScienceDaily. ScienceDaily, 8 October 2009. <www.sciencedaily.com/releases/2009/10/091007124400.htm>.
Henry Ford Health System. (2009, October 8). Genes Signal Late-stage Laryngeal Cancer, Poorer Outcome. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2009/10/091007124400.htm
Henry Ford Health System. "Genes Signal Late-stage Laryngeal Cancer, Poorer Outcome." ScienceDaily. www.sciencedaily.com/releases/2009/10/091007124400.htm (accessed August 28, 2014).

Share This




More Health & Medicine News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com
How A 'Rule Of Thumb' Could Slow Down Drinking

How A 'Rule Of Thumb' Could Slow Down Drinking

Newsy (Aug. 28, 2014) A study suggests people who follow a "rule of thumb" when pouring wine dispense less than those who don't have a particular amount in mind. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins