Featured Research

from universities, journals, and other organizations

Use Of Archived Specimens In Biomarker Studies

Date:
October 8, 2009
Source:
Journal of the National Cancer Institute
Summary:
Researchers are proposing a more efficient system using archived specimens for the evaluation of prognostic and predictive biomarkers.

Researchers propose a more efficient system using archived specimens for the evaluation of prognostic and predictive biomarkers in a new commentary published online October 8 in the Journal of the National Cancer Institute.

The introduction of new biomarkers into routine use in clinical laboratories has been limited partly because of a shortage of prospective studies of marker utility, a lack of reproducibility and reliability among retrospective studies, and low insurance reimbursements for tumor marker tests. In the case of biomarkers for guiding the use of already approved drugs, new prospective studies are sometimes not possible.

Richard M. Simon, DSc, of the Biometric Research Branch at the National Cancer Institute in Bethesda, Md., and colleagues discuss more efficient ways for indirectly testing biomarkers using archived patient tissue specimens, arguing they can be of "great importance for establishing a medical utility of a prognostic or predictive biomarker."

The researchers discuss four conditions that are necessary for this procedure to be useful, which include that representative and sufficient patient samples be available from pivotal clinical trials; biomarker assays be previously validated for use with archived specimens; the strategy for focused analysis of a single marker be fully planned before biomarker evaluation begins; and that results are validated using patient samples from at least one additional clinical trial.

"It is essential to ensure that cancer patients are offered the ben¬efits of valuable prognostic and predictive tests as soon as they are rigorously and reliably evaluated," the authors write. "In this article, we have tried to…propose an update of a level of evidence schema that has been widely used for evalu¬ating… biomarkers in oncology."


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "Use Of Archived Specimens In Biomarker Studies." ScienceDaily. ScienceDaily, 8 October 2009. <www.sciencedaily.com/releases/2009/10/091008161854.htm>.
Journal of the National Cancer Institute. (2009, October 8). Use Of Archived Specimens In Biomarker Studies. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2009/10/091008161854.htm
Journal of the National Cancer Institute. "Use Of Archived Specimens In Biomarker Studies." ScienceDaily. www.sciencedaily.com/releases/2009/10/091008161854.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) — West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) — A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) — Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) — Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins