Featured Research

from universities, journals, and other organizations

Leptin Linked With More Aggressive Thyroid Cancer In Middle Eastern Region

Date:
October 9, 2009
Source:
American Association for Cancer Research
Summary:
Leptin, a molecule linked with obesity, may play a crucial role in predicting poor prognosis from thyroid cancer, at least in the Middle Eastern region of the world, according to new research.

Leptin, a molecule linked with obesity, may play a crucial role in predicting poor prognosis from thyroid cancer, at least in the Middle Eastern region of the world, according to data presented at the American Association for Cancer Research Frontiers in Basic Cancer Research Meeting.

"Leptin receptor expression may be a useful molecular marker in predicting the level of aggression of Middle Eastern thyroid cancer that can help guide treatment options and follow-up care," said lead researcher Khawla S. Al-Kuraya, M.D., director of the research center at King Faisal Specialist Hospital and Research Center in Riyadh, Saudi Arabia.

Thyroid cancer is the eighth most common cancer among American women, but the second most common in Saudi Arabian women. This high prevalence is seen in all Gulf Council countries, according to Al-Kuraya.

Al-Kuraya said there is some evidence that thyroid tumors in the Middle East are unique on a molecular level, particularly an increased amplification of the PIK3CA gene.

For the current study, the researchers focused on measuring the level of leptin and its receptor in 536 human thyroid cancer samples. They found overexpression of the leptin receptor in 80 percent of the cases. This overexpression was significantly associated with poor disease survival. Similarly, increased leptin receptor expression was linked with older age, larger tumor size, advanced stage and metastasis. Furthermore, the researchers have conducted numerous in vitro experiments on thyroid cancer cells in the lab and demonstrated that leptin works on the life process of cancer cells by stimulating growth and preventing death.

Leptin is the product of the "obesity gene" and regulates food intake and energy expenditure. Although this is the first study in which researchers have observed its role in thyroid cancer patients, it has previously been implicated in poor prognosis among patients with gastric, endometrial and breast cancer.

Leptin receptor status can be easily assessed with a fine needle biopsy, according to Al-Kuraya. "This information will be useful in predicting disease aggressiveness and making subsequent treatment decisions about type of surgery, follow-up and iodine dosage," said Al-Kuraya.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Leptin Linked With More Aggressive Thyroid Cancer In Middle Eastern Region." ScienceDaily. ScienceDaily, 9 October 2009. <www.sciencedaily.com/releases/2009/10/091008192731.htm>.
American Association for Cancer Research. (2009, October 9). Leptin Linked With More Aggressive Thyroid Cancer In Middle Eastern Region. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2009/10/091008192731.htm
American Association for Cancer Research. "Leptin Linked With More Aggressive Thyroid Cancer In Middle Eastern Region." ScienceDaily. www.sciencedaily.com/releases/2009/10/091008192731.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins