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Immune Cells Key To Abdominal Drainage

Date:
October 10, 2009
Source:
American Journal of Pathology
Summary:
Researchers have discovered that macrophages, a type of immune cell, impair fluid drainage during peritoneal inflammation. Lymphatic vessels in the diaphragm are responsible for draining excess peritoneal fluid, which lubricates most of the organs in the abdomen. During peritoneal inflammation, however, these vessels have altered structure and function.

Gou Young Koh and colleagues at the Korea Advanced Institute of Science and Technology in Daejeon, Korea have discovered that macrophages, a type of immune cell, impair fluid drainage during peritoneal inflammation. Lymphatic vessels in the diaphragm are responsible for draining excess peritoneal fluid, which lubricates most of the organs in the abdomen. During peritoneal inflammation, however, these vessels have altered structure and function.

To characterize changes in lymphatic vessels during peritoneal inflammation, Kim et al injected the inflammatory molecule LPS into mice to induce peritonitis. LPS injection induced changes in lymphatic vessel structure and function that were reversible upon discontinuation of LPS-induced inflammation. Macrophage migration to these sites of lymphangiogenesis contributed to lymphatic remodeling, and both macrophage attachment to the lymphatic vessels and inflammatory fibrosis resulted in impaired peritoneal fluid drainage. These data highlight the key role of macrophages in inflammation-induced lymphangiogenesis and lymphatic vessel dysfunction in the diaphragm.

This study by Kim et al "reveal[s] that CD11b+ macrophages play an important role in intraperitoneal LPS-induced aberrant lymphangiogenesis and lymphatic dysfunction in the diaphragm." They suggest that "it is possible that human patients with Gram-negative bacterial peritonitis may also have dysfunctional lymphangiogenesis and lymphatic remodeling in the diaphragm."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kim et al. Role of CD11b Macrophages in Intraperitoneal Lipopolysaccharide-Induced Aberrant Lymphangiogenesis and Lymphatic Function in the Diaphragm. American Journal Of Pathology, 2009; 175 (4): 1733 DOI: 10.2353/ajpath.2009.090133

Cite This Page:

American Journal of Pathology. "Immune Cells Key To Abdominal Drainage." ScienceDaily. ScienceDaily, 10 October 2009. <www.sciencedaily.com/releases/2009/10/091010120656.htm>.
American Journal of Pathology. (2009, October 10). Immune Cells Key To Abdominal Drainage. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2009/10/091010120656.htm
American Journal of Pathology. "Immune Cells Key To Abdominal Drainage." ScienceDaily. www.sciencedaily.com/releases/2009/10/091010120656.htm (accessed July 31, 2014).

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