Featured Research

from universities, journals, and other organizations

Immune Cells Key To Abdominal Drainage

Date:
October 10, 2009
Source:
American Journal of Pathology
Summary:
Researchers have discovered that macrophages, a type of immune cell, impair fluid drainage during peritoneal inflammation. Lymphatic vessels in the diaphragm are responsible for draining excess peritoneal fluid, which lubricates most of the organs in the abdomen. During peritoneal inflammation, however, these vessels have altered structure and function.

Gou Young Koh and colleagues at the Korea Advanced Institute of Science and Technology in Daejeon, Korea have discovered that macrophages, a type of immune cell, impair fluid drainage during peritoneal inflammation. Lymphatic vessels in the diaphragm are responsible for draining excess peritoneal fluid, which lubricates most of the organs in the abdomen. During peritoneal inflammation, however, these vessels have altered structure and function.

To characterize changes in lymphatic vessels during peritoneal inflammation, Kim et al injected the inflammatory molecule LPS into mice to induce peritonitis. LPS injection induced changes in lymphatic vessel structure and function that were reversible upon discontinuation of LPS-induced inflammation. Macrophage migration to these sites of lymphangiogenesis contributed to lymphatic remodeling, and both macrophage attachment to the lymphatic vessels and inflammatory fibrosis resulted in impaired peritoneal fluid drainage. These data highlight the key role of macrophages in inflammation-induced lymphangiogenesis and lymphatic vessel dysfunction in the diaphragm.

This study by Kim et al "reveal[s] that CD11b+ macrophages play an important role in intraperitoneal LPS-induced aberrant lymphangiogenesis and lymphatic dysfunction in the diaphragm." They suggest that "it is possible that human patients with Gram-negative bacterial peritonitis may also have dysfunctional lymphangiogenesis and lymphatic remodeling in the diaphragm."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kim et al. Role of CD11b Macrophages in Intraperitoneal Lipopolysaccharide-Induced Aberrant Lymphangiogenesis and Lymphatic Function in the Diaphragm. American Journal Of Pathology, 2009; 175 (4): 1733 DOI: 10.2353/ajpath.2009.090133

Cite This Page:

American Journal of Pathology. "Immune Cells Key To Abdominal Drainage." ScienceDaily. ScienceDaily, 10 October 2009. <www.sciencedaily.com/releases/2009/10/091010120656.htm>.
American Journal of Pathology. (2009, October 10). Immune Cells Key To Abdominal Drainage. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2009/10/091010120656.htm
American Journal of Pathology. "Immune Cells Key To Abdominal Drainage." ScienceDaily. www.sciencedaily.com/releases/2009/10/091010120656.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins