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Popular Antidepressant Associated With A Dramatic Increase In Suicidal Thoughts Amongst Men, Study Finds

Date:
October 15, 2009
Source:
BioMed Central
Summary:
Nortriptyline has been found to cause a tenfold increase in suicidal thoughts in men when compared to its competitor escitalopram, according to a new study.
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Nortriptyline has been found to cause a ten-fold increase in suicidal thoughts in men when compared to its competitor escitalopram. These findings are published in the open access journal BMC Medicine.

The research was carried out by Dr. Nader Perroud from the Institute of Psychiatry, Kings College London, who headed up GENDEP, an international team. Dr Perroud said "Suicidal thoughts and behaviours during antidepressant treatment have prompted warnings by regulatory bodies". He continued "the aim of our study was to investigate the emergence and worsening of suicidal thoughts during treatment with two different types of antidepressant."

Both escitalopram and nortriptyline have their effect through the mood modulating neurotransmitter systems. The former is a selective serotonin reuptake inhibitor (SSRI), preventing serotonin from re-entering the cell and thereby prolonging its effect on nerve synapses. The latter is a tricyclic antidepressant that inhibits the reuptake of noradrenaline, and to a lesser extent, that of serotonin.

The study was carried out on 811 individuals with moderate to severe unipolar depression. Whilst an overall trend in reduction of suicidal thoughts was observed, men who took nortriptyline were found to have a 9.8-fold increase in emerging suicidal thoughts and a 2.4-fold increase in worsening suicidal thoughts compared to those who took escitalopram.

Perroud concludes, "Our findings that treatment-emerging and worsening suicidal thoughts may also be associated with psychomotor activation triggered by antidepressants needs to be investigated in future studies. The study also refutes the idea that newer antidepressants such as the SSRIs are worse than older medications in terms of increasing suicidal thoughts."


Story Source:

The above post is reprinted from materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nader Perroud, Rudolf Uher, Andrej Marusic, Marcella Rietschel, Ole Mors, Neven Henigsberg, Joanna Hauser, Wolfgang Maier, Daniel Souery, Anna Placentino, Aleksandra Szczepankiewicz, Lisbeth Jorgensen, Jana Strohmaier, Astrid Zobel, Caterina Giovannini, Amanda Elkin, Cerisse Gunasinghe, Joanna Gray, Desmond Campbell, Bhanu Gupta, Anne E Farmer, Peter McGuffin and Katherine J Aitchison. Suicidal ideation during treatment of depression with escitalopram and nortriptyline in Genome-Based Therapeutic Drugs for Depression (GENDEP): a clinical trial. BMC Medicine, 2009; (in press) [link]

Cite This Page:

BioMed Central. "Popular Antidepressant Associated With A Dramatic Increase In Suicidal Thoughts Amongst Men, Study Finds." ScienceDaily. ScienceDaily, 15 October 2009. <www.sciencedaily.com/releases/2009/10/091014193213.htm>.
BioMed Central. (2009, October 15). Popular Antidepressant Associated With A Dramatic Increase In Suicidal Thoughts Amongst Men, Study Finds. ScienceDaily. Retrieved July 27, 2015 from www.sciencedaily.com/releases/2009/10/091014193213.htm
BioMed Central. "Popular Antidepressant Associated With A Dramatic Increase In Suicidal Thoughts Amongst Men, Study Finds." ScienceDaily. www.sciencedaily.com/releases/2009/10/091014193213.htm (accessed July 27, 2015).

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