Featured Research

from universities, journals, and other organizations

Bowels Of Infection: Cytomegalovirus Infection May Exacerbate Inflammatory Bowel Disease

Date:
November 3, 2009
Source:
American Journal of Pathology
Summary:
New research suggests that latent cytomegalovirus infection may exacerbate inflammatory bowel disease.

Current research suggests that latent cytomegalovirus (CMV) infection may exacerbate inflammatory bowel disease (IBD). The related report by Onyeagocha et al, "Latent cytomegalovirus infection exacerbates experimental colitis," appears in the November 2009 issue of The American Journal of Pathology.

CMV infects between 50% and 80% of adults in the United States. Most people who are infected have no symptoms, and the virus remains hidden but inactive in the body for the rest of the person's life unless activated by suppression of the immune system.

IBD, which affects between 1 and 1.4 million people in the United States, causes pain, vomiting, and diarrhea in affected individuals as well as leads to an increased risk for colorectal cancer. Acute CMV infection exacerbates IBD; however, the effects of latent CMV infection on the development and/or severity of IBD have not been studied.

Researchers led by Dr. Andrew Gewirtz at Emory University in Atlanta, GA therefore examined IBD development in mice with latent CMV infection. They found that while latent CMV infection did not induce IBD, it exacerbated the severity of intestinal inflammation if colitis were already present. In addition, CMV infection resulted in increased levels of intestinal white blood cells and heightened immune responses to normally harmless bacteria found in the intestine; which are associated with IBD severity. Therefore, modulation of mucosal immunity by latent CMV infection may contribute to the pathogenesis of IBD.

Onyeagocha et al suggest that "latent infection by CMV, and perhaps other common viruses, may modulate mucosal immunity and, consequently, alter one's susceptibility to developing severe acute colitis in response to various challenges and, consequently, may predispose to developing IBD." In future studies, Dr. Gewirtz and colleagues plan to use "retrospective serologic analysis [to] confirm the notion that latent CMV infection increases risk of developing IBD. [Although vaccines to CMV are no yet available, these results suggest that] it may be advisable to consider vaccinating healthy young populations against this virus even in the absence of any risk factors that such individuals are ever likely to be in an immunocompromised state."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Onyeagocha C, Hossain MS, Kumar A, Jones RM, Roback J, Gewirtz AT. Latent Cytomegalovirus Infection Exacerbates Experimental Colitis. American Journal Of Pathology, 2009; DOI: 10.2353/ajpath.2009.090471

Cite This Page:

American Journal of Pathology. "Bowels Of Infection: Cytomegalovirus Infection May Exacerbate Inflammatory Bowel Disease." ScienceDaily. ScienceDaily, 3 November 2009. <www.sciencedaily.com/releases/2009/10/091021100516.htm>.
American Journal of Pathology. (2009, November 3). Bowels Of Infection: Cytomegalovirus Infection May Exacerbate Inflammatory Bowel Disease. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2009/10/091021100516.htm
American Journal of Pathology. "Bowels Of Infection: Cytomegalovirus Infection May Exacerbate Inflammatory Bowel Disease." ScienceDaily. www.sciencedaily.com/releases/2009/10/091021100516.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins