Featured Research

from universities, journals, and other organizations

Childhood Risk Factors For Developing Substance Dependence

Date:
October 22, 2009
Source:
Elsevier
Summary:
There is ample evidence for the genetic influence of alcohol dependence, and ongoing studies are actively looking for specific genes that may confer this increased susceptibility.

There is ample evidence for the genetic influence of alcohol dependence, and ongoing studies are actively looking for specific genes that may confer this increased susceptibility. In addition, while it is well-known that individual risk is increased with the number of relatives with alcohol dependence, scientists have not been in a position to identify who among these individuals might have greater or lesser risk.

Biological Psychiatry is now publishing an article in which researchers evaluated and identified childhood risk factors for the development of future substance use disorders (SUD).

Dr. Shirley Hill and her colleagues recruited children with either high or low familial risk for developing alcohol dependence and followed them annually over an eleven-year span. During this time, they repeatedly evaluated a series of thirteen predictors that are thought to influence familial risk, including educational achievement scores, personality variables, self-esteem, and anxiety, along with specific neurobiological variables (P300 amplitude, a brain neuroelectric potential, and postural body sway).

They found that children with increased body sway and reduced P300 amplitude had an 8-fold increase in their likelihood of developing a substance use disorder by young adulthood, indicating that neurobiological variables are among the most important in predicting outcome. "The P300 is a brain signal that is associated with the significance of events in our environment and may reflect an individual's ability to make optimal use of such information to guide future behavior. It is both interesting and important that the long-term risk for developing alcohol dependence can be connected to this relatively basic feature of brain wiring," explained Dr. John Krystal, Editor of Biological Psychiatry.

Dr. Hill commented that these results are important "in showing that risk markers for alcohol dependence and other substance use disorders can be identified long before individuals develop symptoms of these disorders. Better and earlier identification of those at highest risk makes it possible to develop targeted intervention/prevention efforts for these children, possibly enabling them to avoid [this] outcome." In addition, uncovering these childhood risk markers aids in the search for genes associated with the development of substance use disorders.

John H. Krystal, M.D. is Chairman of the Department of Psychiatry at the Yale University School of Medicine and a research psychiatrist at the VA Connecticut Healthcare System.


Story Source:

The above story is based on materials provided by Elsevier. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hill et al. Childhood Risk Factors for Young Adult Substance Dependence Outcome in Offspring from Multiplex Alcohol Dependence Families: A Prospective Study. Biological Psychiatry, 2009; 66 (8): 750 DOI: 10.1016/j.biopsych.2009.05.030

Cite This Page:

Elsevier. "Childhood Risk Factors For Developing Substance Dependence." ScienceDaily. ScienceDaily, 22 October 2009. <www.sciencedaily.com/releases/2009/10/091021100740.htm>.
Elsevier. (2009, October 22). Childhood Risk Factors For Developing Substance Dependence. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2009/10/091021100740.htm
Elsevier. "Childhood Risk Factors For Developing Substance Dependence." ScienceDaily. www.sciencedaily.com/releases/2009/10/091021100740.htm (accessed September 2, 2014).

Share This




More Mind & Brain News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
Coffee Then Napping: The (New) Key To Alertness

Coffee Then Napping: The (New) Key To Alertness

Newsy (Aug. 30, 2014) Researchers say having a cup of coffee then taking a nap is more effective than a nap or coffee alone. Video provided by Newsy
Powered by NewsLook.com
Young Entrepreneurs Get $100,000, If They Quit School

Young Entrepreneurs Get $100,000, If They Quit School

AFP (Aug. 29, 2014) Twenty college-age students are getting 100,000 dollars from a Silicon Valley leader and a chance to live in San Francisco in order to work on the start-up project of their dreams, but they have to quit school first. Duration: 02:20 Video provided by AFP
Powered by NewsLook.com
Baby Babbling Might Lead To Faster Language Development

Baby Babbling Might Lead To Faster Language Development

Newsy (Aug. 29, 2014) A new study suggests babies develop language skills more quickly if their parents imitate the babies' sounds and expressions and talk to them often. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins