Featured Research

from universities, journals, and other organizations

Adding Ezetimibe To Atorvastatin Improves Lipid Control, Study Finds

Date:
October 27, 2009
Source:
Heart and Stroke Foundation of Canada
Summary:
Adding ezetimibe to atorvastatin significantly boosted the attainment of lipid targets as specified by both Canadian and European guidelines in elderly patients aged 65 and older and the combination produced superior results than simply increasing the dose of atorvastatin alone, a new study shows.

Adding ezetimibe to atorvastatin significantly boosted the attainment of lipid targets as specified by both Canadian and European guidelines in elderly patients aged 65 and older and the combination produced superior results than simply increasing the dose of atorvastatin alone, Dr. Christian Constance told the Canadian Cardiovascular Congress 2009, co-hosted by the Heart and Stroke Foundation and the Canadian Cardiovascular Society.

Related Articles


"The population of people age 65 and older is growing but very few studies have looked at the efficacy of lipid-lowering drugs in this group of patients. We wanted to see whether adding ezetimibe to atorvastatin would be as effective as doubling or even quadrupling the dose of atorvastatin in this age group," said Dr. Constance, of the University of Montreal.

The study included 2,055 patients who were at high risk for coronary heart disease or who had been diagnosed with arterial vascular disease and who were not at the following cholesterol targets:

  • Less than 2 mmol/L for low density lipoprotein cholesterol (LDL-C)
  • Less than 4 mmol/L for total cholesterol (TC)
  • TC to high density lipoprotein cholesterol (HDL) ratio less than 4
  • Less than 0.85g/L for apolipoprotein B (ApoB)
  • Less than 1.0 mg/L for high sensitivity-C-reactive protein (hs-CRP)

The patients were stabilized on atorvastatin 10 mg/day for six weeks and then were randomized to receive either ezetimibe 10 mg/day in addition to atorvastatin 10 mg/day for 12 weeks or to atorvastatin 20 mg/day for six weeks, followed by a quadrupling of atorvastatin to 40 mg/day for six weeks. Significantly more patients achieved their lipid targets with the ezetimibe plus atorvastatin combination compared with double or quadruple dose monotherapy with atorvastatin. For example, the percent of patients achieving their LDL-C targets on the ezetimibe/atorvastatin combination at 12 weeks was 60.5% compared with 49.7% for patients on the atorvastatin 20mg/40mg regimen [Odds ratio (95% CI)1.55 (1.21, 1.98)].

All treatments were well tolerated.

"Whether you look at European LDL targets or Canadian LDL targets, we reached LDL targets much easier with the combination ezetimibe atorvastatin 10 mg. than even atorvastatin 40 mg. The European guidelines are a little more strict," Dr. Constance said.

"It's a numbers game," he added. "The more you get to those targets, the less patients will have events. And the lower dose of statin, the better it is tolerated, especially in the older, high risk patients, who were the subjects of this study."

The differences between the LDL-cholesterol levels that were achieved were quite striking, said Dr. Charles Kerr, president of the Canadian Cardiovascular Society. "This is a very well-designed trial and the evidence is very convincing that adding ezetimibe to a lower dose of atorvastatin may be more effective than just increasing the dose. Essentially what we have been doing with the statin drugs is doubling them until we achieve goal."

Ezetimibe is a cholesterol lowering drug that acts differently from the statins, he added. "Ezetimibe blocks the absorption of cholesterol from the gut; whereas statins alter metabolism in the liver. This study suggests that adding ezetimibe can be an effective way of reducing cholesterol perhaps more so than increasing the doses of statins."


Story Source:

The above story is based on materials provided by Heart and Stroke Foundation of Canada. Note: Materials may be edited for content and length.


Cite This Page:

Heart and Stroke Foundation of Canada. "Adding Ezetimibe To Atorvastatin Improves Lipid Control, Study Finds." ScienceDaily. ScienceDaily, 27 October 2009. <www.sciencedaily.com/releases/2009/10/091027085258.htm>.
Heart and Stroke Foundation of Canada. (2009, October 27). Adding Ezetimibe To Atorvastatin Improves Lipid Control, Study Finds. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2009/10/091027085258.htm
Heart and Stroke Foundation of Canada. "Adding Ezetimibe To Atorvastatin Improves Lipid Control, Study Finds." ScienceDaily. www.sciencedaily.com/releases/2009/10/091027085258.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com
Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins