Featured Research

from universities, journals, and other organizations

Foreskin Surface Area And HIV Acquisition: Size Matters

Date:
October 29, 2009
Source:
Wolters Kluwer Health / Lippincott Williams & Wilkins
Summary:
Randomized clinical trials conducted by researchers in Rakai, Uganda, have revealed a link between the size of foreskin surface area and the risk of male HIV acquisition.

Randomized clinical trials conducted by researchers in Rakai, Uganda, have revealed a link between the size of foreskin surface area and the risk of male HIV acquisition.

The results of the trials have been published in the current issue of AIDS, the leading journal in the field of HIV and AIDS research. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health, a leading provider of information and business intelligence for students, professionals, and institutions in medicine, nursing, allied health, and pharmacy.

In recent years, several studies have shown that circumcision reduces the risk of male HIV acquisition by 50-60%, and circumcision is now recommended by WHO/United Nations Joint Programme on HIV/AIDS (UNAIDS) as an HIV prevention strategy. Based on this evidence that the foreskin increases vulnerability to HIV, Dr Godfrey Kigozi and his colleagues hypothesized that the size of the foreskin might be related to the risk of HIV infection.

Eligible candidates for this retrospective cohort study were drawn from the initially HIV-negative participants in the Rakai Community Cohort Study. These men were subsequently enrolled into the randomized trials of male circumcision and had measurement of their foreskin surface area taken following surgery. The researchers then determined HIV acquisition in these men and assessed the association between foreskin size measured after surgery, and the incidence of HIV acquisition while under surveillance prior to circumcision. Their results determined that the risk of male HIV acquisition was significantly increased in men with larger foreskin surface areas.

The researchers point out that their study is unique and their findings therefore need to be replicated. However, these results, in addition to the observational studies and randomized trials, add plausibility to the hypothesis that the foreskin is a tissue vulnerable to HIV acquisition.


Story Source:

The above story is based on materials provided by Wolters Kluwer Health / Lippincott Williams & Wilkins. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kigozi, Godfrey; Wawer, Maria; Ssettuba, Absalom; Kagaayi, Joseph; Nalugoda, Fred; Watya, Stephen; Mangen, Fred Wabwire; Kiwanuka, Noah; Bacon, Melanie C; Lutalo, Tom; Serwadda, David; Gray, Ronald H. Foreskin surface area and HIV acquisition in Rakai, Uganda (size matters). AIDS, 2009; 23 (16): 2209 DOI: 10.1097/QAD.0b013e328330eda8

Cite This Page:

Wolters Kluwer Health / Lippincott Williams & Wilkins. "Foreskin Surface Area And HIV Acquisition: Size Matters." ScienceDaily. ScienceDaily, 29 October 2009. <www.sciencedaily.com/releases/2009/10/091029161728.htm>.
Wolters Kluwer Health / Lippincott Williams & Wilkins. (2009, October 29). Foreskin Surface Area And HIV Acquisition: Size Matters. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2009/10/091029161728.htm
Wolters Kluwer Health / Lippincott Williams & Wilkins. "Foreskin Surface Area And HIV Acquisition: Size Matters." ScienceDaily. www.sciencedaily.com/releases/2009/10/091029161728.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins