Featured Research

from universities, journals, and other organizations

Foreskin Surface Area And HIV Acquisition: Size Matters

Date:
October 29, 2009
Source:
Wolters Kluwer Health / Lippincott Williams & Wilkins
Summary:
Randomized clinical trials conducted by researchers in Rakai, Uganda, have revealed a link between the size of foreskin surface area and the risk of male HIV acquisition.

Randomized clinical trials conducted by researchers in Rakai, Uganda, have revealed a link between the size of foreskin surface area and the risk of male HIV acquisition.

Related Articles


The results of the trials have been published in the current issue of AIDS, the leading journal in the field of HIV and AIDS research. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health, a leading provider of information and business intelligence for students, professionals, and institutions in medicine, nursing, allied health, and pharmacy.

In recent years, several studies have shown that circumcision reduces the risk of male HIV acquisition by 50-60%, and circumcision is now recommended by WHO/United Nations Joint Programme on HIV/AIDS (UNAIDS) as an HIV prevention strategy. Based on this evidence that the foreskin increases vulnerability to HIV, Dr Godfrey Kigozi and his colleagues hypothesized that the size of the foreskin might be related to the risk of HIV infection.

Eligible candidates for this retrospective cohort study were drawn from the initially HIV-negative participants in the Rakai Community Cohort Study. These men were subsequently enrolled into the randomized trials of male circumcision and had measurement of their foreskin surface area taken following surgery. The researchers then determined HIV acquisition in these men and assessed the association between foreskin size measured after surgery, and the incidence of HIV acquisition while under surveillance prior to circumcision. Their results determined that the risk of male HIV acquisition was significantly increased in men with larger foreskin surface areas.

The researchers point out that their study is unique and their findings therefore need to be replicated. However, these results, in addition to the observational studies and randomized trials, add plausibility to the hypothesis that the foreskin is a tissue vulnerable to HIV acquisition.


Story Source:

The above story is based on materials provided by Wolters Kluwer Health / Lippincott Williams & Wilkins. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kigozi, Godfrey; Wawer, Maria; Ssettuba, Absalom; Kagaayi, Joseph; Nalugoda, Fred; Watya, Stephen; Mangen, Fred Wabwire; Kiwanuka, Noah; Bacon, Melanie C; Lutalo, Tom; Serwadda, David; Gray, Ronald H. Foreskin surface area and HIV acquisition in Rakai, Uganda (size matters). AIDS, 2009; 23 (16): 2209 DOI: 10.1097/QAD.0b013e328330eda8

Cite This Page:

Wolters Kluwer Health / Lippincott Williams & Wilkins. "Foreskin Surface Area And HIV Acquisition: Size Matters." ScienceDaily. ScienceDaily, 29 October 2009. <www.sciencedaily.com/releases/2009/10/091029161728.htm>.
Wolters Kluwer Health / Lippincott Williams & Wilkins. (2009, October 29). Foreskin Surface Area And HIV Acquisition: Size Matters. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2009/10/091029161728.htm
Wolters Kluwer Health / Lippincott Williams & Wilkins. "Foreskin Surface Area And HIV Acquisition: Size Matters." ScienceDaily. www.sciencedaily.com/releases/2009/10/091029161728.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins