Featured Research

from universities, journals, and other organizations

Largest-ever database for liver proteins may lead to treatments for hepatitis

Date:
November 13, 2009
Source:
American Chemical Society
Summary:
Scientists in China are reporting for the first time assembly of the largest-ever collection of data about the proteins produced by genes in a single human organ. Their focus was the liver, and their massive database in both protein and transcript levels could become a roadmap for finding possible new biomarkers and treatments for liver disease. Those include hepatitis and liver cancer, which is at epidemic levels in China and affects millions of people worldwide.

Scientists at a group of 11 research centers in China are reporting for the first time assembly of the largest-ever collection of data about the proteins produced by genes in a single human organ. Their focus was the liver, and their massive database in both protein and transcript levels could become a roadmap for finding possible new biomarkers and treatments for liver disease.

Those include hepatitis and liver cancer, which is at epidemic levels in China and affects millions of people worldwide.

Part of the China Human Liver Proteome Project, which was officially launched by the Ministry of Science and Technology of China (MOST) and chaired by Fuchu He, the study appears online in ACS' Journal of Proteome Research.

He and colleagues point out that the liver plays many essential roles in the body, such as producing digestive enzymes, hormones, most of the proteins in the blood, storing carbohydrates for use in supplying energy to the muscles, and activates and breaks down drugs. Despite that key role, huge gaps likely exist in scientific knowledge about proteins involved in these activities.

Using 10 tissue samples of healthy liver from volunteers, they identified 6,788 non-redundant proteins in the liver samples, the largest group of proteins ever identified by scientists in any human organ. Half of the proteins have never been seen in the human liver before. One intriguing and unexplained discovery: Many of the new-found proteins appear related to diseases in the nervous system.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chinese Human Liver Proteome Profiling Consortium. First Insight into the Human Liver Proteome from PROTEOMESKY -LIVERHu 1.0, a Publicly Available Database. Journal of Proteome Research, 2009 [link]

Cite This Page:

American Chemical Society. "Largest-ever database for liver proteins may lead to treatments for hepatitis." ScienceDaily. ScienceDaily, 13 November 2009. <www.sciencedaily.com/releases/2009/11/091111123614.htm>.
American Chemical Society. (2009, November 13). Largest-ever database for liver proteins may lead to treatments for hepatitis. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2009/11/091111123614.htm
American Chemical Society. "Largest-ever database for liver proteins may lead to treatments for hepatitis." ScienceDaily. www.sciencedaily.com/releases/2009/11/091111123614.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com
What's To Blame For Worst Ebola Outbreak In History?

What's To Blame For Worst Ebola Outbreak In History?

Newsy (July 27, 2014) A U.S. doctor has tested positive for the deadly Ebola virus, as the worst-ever outbreak continues to grow. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins