Featured Research

from universities, journals, and other organizations

Exposure to both traffic, indoor pollutants puts some kids at higher risk for asthma later

Date:
November 27, 2009
Source:
University of Cincinnati Academic Health Center
Summary:
New research presents strong evidence that the "synergistic" effect of early-life exposure to both outdoor traffic-related pollution and indoor endotoxin causes more harm to developing lungs than one or the other exposure alone.

New research presents strong evidence that the "synergistic" effect of early-life exposure to both outdoor traffic-related pollution and indoor endotoxin causes more harm to developing lungs than one or the other exposure alone.

Environmental health scientists at the University of Cincinnati (UC) College of Medicine have shown that children exposed to both high levels of traffic-related particles and indoor endotoxin during early life are six times more likely to experience persistent wheezing than children exposed to low levels of traffic and indoor-related pollutants.

They report their findings in the Dec. 1, 2009, edition of the American Journal of Respiratory and Critical Care Medicine. This is believed to be the first study to look at the combined effects of traffic-related exposures and sampled endotoxin in children during infancy as an indicator of asthma later in life. Endotoxin, a component of bacteria thought to trigger an immune response in humans, was measured from dust samples collected prior to age 1.

Based on a long-term study of children deemed at high risk for allergies later in life, UC environmental health researchers have found that 36 percent of the children studied who were exposed to high levels of both traffic-related pollution and indoor endotoxin demonstrated persistent wheezing at age 3, an early warning sign of asthma and other pulmonary conditions. Only 11 percent of children exposed to low levels of both indoor and outdoor allergens experienced wheezing; 18 percent of children exposed to low levels of indoor endotoxin and high levels of traffic-related particles experienced persistent wheezing. Endotoxin exposure alone appeared to have little effect.

"There is a clear synergistic effect from co-exposure to traffic-related particles and endotoxin above and beyond what you would see with a single exposure that can be connected to persistent wheezing by age 3," explains Patrick Ryan, PhD, lead author of the study and a research assistant professor of environmental health at UC."These two exposure sources -- when simultaneously present at high levels -- appear to work together to negatively impact the health of young children with developing lungs."

To conduct this study, Ryan and his colleagues utilized land-use regression modeling to calculate study participants' exposures to traffic-related particles, such as diesel exhaust. The model was designed to capture exposures at locations where the child spent more than eight hours a week between birth and age 3; for example, in their homes or at day care.

"Traffic-related particles and endotoxin both seem to trigger an inflammatory response in the children monitored in this study. When put together, that effect is amplified to have a greater impact on the body's response," adds Ryan. "The earlier in life this type of exposure occurs, the more impact it may have long term. Lung development occurs in children up through age 18 or 20. Exposure earlier in life to both endotoxin and traffic will have a greater impact on developing lungs compared to adults whose lungs are already developed."

This research is part of the Cincinnati Childhood Allergy and Air Pollution Study, a long-term epidemiological study examining the effects of traffic particulates on childhood respiratory health and allergy development. Funded by the National Institute of Environmental Health Sciences, the study began in 2001 and is led by Grace LeMasters, PhD, of the UC Department of Environmental Health. Study participants were chosen based on family history and residence's proximity to a major road.

UC's LeMasters, David Bernstein, MD, James Lockey, MD, Tiina Reponen, PhD, Linda Levin, PhD, Sergey Grinshpun, PhD, Manuel Villareal, MD and Jeff Burkle were co-authors of the study. Gurjit Khurana Hershey, MD, PhD, of Cincinnati Children's Hospital Medical Center also participated in the research study.


Story Source:

The above story is based on materials provided by University of Cincinnati Academic Health Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Cincinnati Academic Health Center. "Exposure to both traffic, indoor pollutants puts some kids at higher risk for asthma later." ScienceDaily. ScienceDaily, 27 November 2009. <www.sciencedaily.com/releases/2009/11/091124082753.htm>.
University of Cincinnati Academic Health Center. (2009, November 27). Exposure to both traffic, indoor pollutants puts some kids at higher risk for asthma later. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2009/11/091124082753.htm
University of Cincinnati Academic Health Center. "Exposure to both traffic, indoor pollutants puts some kids at higher risk for asthma later." ScienceDaily. www.sciencedaily.com/releases/2009/11/091124082753.htm (accessed July 25, 2014).

Share This




More Earth & Climate News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Goma Cheese Brings Whiff of New Hope to DRC

Goma Cheese Brings Whiff of New Hope to DRC

Reuters - Business Video Online (July 24, 2014) The eastern region of the Democratic Republic of Congo, mainly known for conflict and instability, is an unlikely place for the production of fine cheese. But a farm in the village of Masisi, in North Kivu is slowly transforming perceptions of the area. Known simply as Goma cheese, the Congolese version of Dutch gouda has gained popularity through out the region. Ciara Sutton reports. Video provided by Reuters
Powered by NewsLook.com
Bill Gates: Health, Agriculture Key to Africa's Development

Bill Gates: Health, Agriculture Key to Africa's Development

AFP (July 24, 2014) Health and agriculture development are key if African countries are to overcome poverty and grow, US software billionaire Bill Gates said Thursday, as he received an honourary degree in Ethiopia. Duration: 00:36 Video provided by AFP
Powered by NewsLook.com
Higgins Breaks Record at Mt. Washington

Higgins Breaks Record at Mt. Washington

Driving Sports (July 24, 2014) Subaru Rally Team USA drivers David Higgins and Travis Pastrana face off against a global contingent of racers at the annual Mt. Washington Hillclimb in New Hampshire. Includes exclusive in-car footage from Higgins' record attempt. Video provided by Driving Sports
Powered by NewsLook.com
Storm Kills Three, Injures 20 at Virginia Campground

Storm Kills Three, Injures 20 at Virginia Campground

Reuters - US Online Video (July 24, 2014) A likely tornado tears through an eastern Virginia campground, killing three and injuring at least 20. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins