Featured Research

from universities, journals, and other organizations

Exposure to both traffic, indoor pollutants puts some kids at higher risk for asthma later

Date:
November 27, 2009
Source:
University of Cincinnati Academic Health Center
Summary:
New research presents strong evidence that the "synergistic" effect of early-life exposure to both outdoor traffic-related pollution and indoor endotoxin causes more harm to developing lungs than one or the other exposure alone.

New research presents strong evidence that the "synergistic" effect of early-life exposure to both outdoor traffic-related pollution and indoor endotoxin causes more harm to developing lungs than one or the other exposure alone.

Environmental health scientists at the University of Cincinnati (UC) College of Medicine have shown that children exposed to both high levels of traffic-related particles and indoor endotoxin during early life are six times more likely to experience persistent wheezing than children exposed to low levels of traffic and indoor-related pollutants.

They report their findings in the Dec. 1, 2009, edition of the American Journal of Respiratory and Critical Care Medicine. This is believed to be the first study to look at the combined effects of traffic-related exposures and sampled endotoxin in children during infancy as an indicator of asthma later in life. Endotoxin, a component of bacteria thought to trigger an immune response in humans, was measured from dust samples collected prior to age 1.

Based on a long-term study of children deemed at high risk for allergies later in life, UC environmental health researchers have found that 36 percent of the children studied who were exposed to high levels of both traffic-related pollution and indoor endotoxin demonstrated persistent wheezing at age 3, an early warning sign of asthma and other pulmonary conditions. Only 11 percent of children exposed to low levels of both indoor and outdoor allergens experienced wheezing; 18 percent of children exposed to low levels of indoor endotoxin and high levels of traffic-related particles experienced persistent wheezing. Endotoxin exposure alone appeared to have little effect.

"There is a clear synergistic effect from co-exposure to traffic-related particles and endotoxin above and beyond what you would see with a single exposure that can be connected to persistent wheezing by age 3," explains Patrick Ryan, PhD, lead author of the study and a research assistant professor of environmental health at UC."These two exposure sources -- when simultaneously present at high levels -- appear to work together to negatively impact the health of young children with developing lungs."

To conduct this study, Ryan and his colleagues utilized land-use regression modeling to calculate study participants' exposures to traffic-related particles, such as diesel exhaust. The model was designed to capture exposures at locations where the child spent more than eight hours a week between birth and age 3; for example, in their homes or at day care.

"Traffic-related particles and endotoxin both seem to trigger an inflammatory response in the children monitored in this study. When put together, that effect is amplified to have a greater impact on the body's response," adds Ryan. "The earlier in life this type of exposure occurs, the more impact it may have long term. Lung development occurs in children up through age 18 or 20. Exposure earlier in life to both endotoxin and traffic will have a greater impact on developing lungs compared to adults whose lungs are already developed."

This research is part of the Cincinnati Childhood Allergy and Air Pollution Study, a long-term epidemiological study examining the effects of traffic particulates on childhood respiratory health and allergy development. Funded by the National Institute of Environmental Health Sciences, the study began in 2001 and is led by Grace LeMasters, PhD, of the UC Department of Environmental Health. Study participants were chosen based on family history and residence's proximity to a major road.

UC's LeMasters, David Bernstein, MD, James Lockey, MD, Tiina Reponen, PhD, Linda Levin, PhD, Sergey Grinshpun, PhD, Manuel Villareal, MD and Jeff Burkle were co-authors of the study. Gurjit Khurana Hershey, MD, PhD, of Cincinnati Children's Hospital Medical Center also participated in the research study.


Story Source:

The above story is based on materials provided by University of Cincinnati Academic Health Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Cincinnati Academic Health Center. "Exposure to both traffic, indoor pollutants puts some kids at higher risk for asthma later." ScienceDaily. ScienceDaily, 27 November 2009. <www.sciencedaily.com/releases/2009/11/091124082753.htm>.
University of Cincinnati Academic Health Center. (2009, November 27). Exposure to both traffic, indoor pollutants puts some kids at higher risk for asthma later. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2009/11/091124082753.htm
University of Cincinnati Academic Health Center. "Exposure to both traffic, indoor pollutants puts some kids at higher risk for asthma later." ScienceDaily. www.sciencedaily.com/releases/2009/11/091124082753.htm (accessed April 18, 2014).

Share This



More Earth & Climate News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Great British Farmland Boom

The Great British Farmland Boom

Reuters - Business Video Online (Apr. 17, 2014) Britain's troubled Co-operative Group is preparing to cash in on nearly 18,000 acres of farmland in one of the biggest UK land sales in decades. As Ivor Bennett reports, the market timing couldn't be better, with farmland prices soaring over 270 percent in the last 10 years. Video provided by Reuters
Powered by NewsLook.com
Small Reactors Could Be Future of Nuclear Energy

Small Reactors Could Be Future of Nuclear Energy

AP (Apr. 17, 2014) After the Fukushima nuclear disaster, the industry fell under intense scrutiny. Now, small underground nuclear power plants are being considered as the possible future of the nuclear energy. (April 17) Video provided by AP
Powered by NewsLook.com
Change of Diet Helps Crocodile Business

Change of Diet Helps Crocodile Business

Reuters - Business Video Online (Apr. 16, 2014) Crocodile farming has been a challenge in Zimbabwe in recent years do the economic collapse and the financial crisis. But as Ciara Sutton reports one of Europe's biggest suppliers of skins to the luxury market has come up with an unusual survival strategy - vegetarian food. Video provided by Reuters
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins