Featured Research

from universities, journals, and other organizations

Molecule discovered that makes obese people develop diabetes

Date:
November 27, 2009
Source:
FECYT - Spanish Foundation for Science and Technology
Summary:
Many people who are overweight or obese develop insulin resistance and type 2 diabetes at some stage in their lives. Scientists have now discovered that obese people have large amounts of the molecule CXCL5, produced by certain cells in fatty tissue.

Many people who are overweight or obese develop insulin resistance and type 2 diabetes at some stage in their lives. A European research team has now discovered that obese people have large amounts of the molecule CXCL5, produced by certain cells in fatty tissue.

The main risk factors for type 2 diabetes are obesity and a sedentary lifestyle. The biomedical community has known for many years that substances produced by fatty tissue are responsible for the link between obesity and diabetes. "Chronic inflammation of the adipose tissue, which is characteristic of obese people, is a crucial stage in the development of insulin resistence and type 2 diabetes," Lluis Fajas, lead author of the study and a researcher at the Institute of Health and Medical Research (Inserm) in France, said.

The results of this new study show that serum levels of a chemokine molecule called CXCL5, produced by certain adipose tissue cells, appear at much high levels in the tissues of obese people than in those of individuals with normal weight. This has helped Lluis Fajas's research team to come to a biomedically relevant conclusion: "The CXCL5 molecule helps cause insulin resistance and type 2 diabetes".

The most important part of this study, published in the journal Cell Metabolism, is the discovery that an experimental treatment aimed at inhibiting the action of CXCL5 can help to protect obese mice from develping type 2 diabetes. "If these studies can be confirmed in humans, this treatment would represent a fundamental improvement in the quality of life of obese individuals," the researcher concludes.

Bad habits cause obesity and diabetes

According to the latest data from the Spanish Diabetes Federation (FED), almost 3.5 million people in Spain have diabetes. This illness is most common in Andalusia and Murcia, regions where the highest percentage of people who are obese and sedentary. The specialists agree on the importance of prevention. Avoiding obesity, doing daily physical exercise and giving up smoking are some of the measures that could help to cut the number of diabetes cases by a half.

The International Diabetes Federation (IDF) says that more than 190 million people worldwide currently have diabetes. This figure will rise to 330 million by 2025, due to population growth, the ageing of the population, and increasing urbanisation and sedentary lifestyles. Obesity is the main avoidable risk factor in developing type 2 diabetes. Worldwide, 1.7 billion people are already at high risk of developing a non-contagious, weight-related illness, such as type 2 diabetes.

Obesity can reduce the life expectancy of people with type 2 diabetes by up to eight years, and 80% of people diagnosed with the illness are overweight at the time they are diagnosed.

At least half of all cases of type 2 diabetes among adults could be avoided if they did not put on weight. Taking action on lifestyle, such as changing diet and taking moderate physical exercise, can reduce the risk of developing type 2 diabetes by up to 60%.


Story Source:

The above story is based on materials provided by FECYT - Spanish Foundation for Science and Technology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chavey et al. CXC Ligand 5 Is an Adipose-Tissue Derived Factor that Links Obesity to Insulin Resistance. Cell Metabolism, 2009; 9 (4): 339 DOI: 10.1016/j.cmet.2009.03.002

Cite This Page:

FECYT - Spanish Foundation for Science and Technology. "Molecule discovered that makes obese people develop diabetes." ScienceDaily. ScienceDaily, 27 November 2009. <www.sciencedaily.com/releases/2009/11/091124103617.htm>.
FECYT - Spanish Foundation for Science and Technology. (2009, November 27). Molecule discovered that makes obese people develop diabetes. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2009/11/091124103617.htm
FECYT - Spanish Foundation for Science and Technology. "Molecule discovered that makes obese people develop diabetes." ScienceDaily. www.sciencedaily.com/releases/2009/11/091124103617.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins