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New cause for Alzheimer's disease?

Date:
November 27, 2009
Source:
American Journal of Pathology
Summary:
Scientists have discovered that a precursor to nerve growth factor (pro-NGF) may play a pathogenic role in Alzheimer's disease.
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Dr. Carme Espinet and colleagues at the University of Lleida, Lleida, Spain have discovered that a precursor to nerve growth factor (pro-NGF) may play a pathogenic role in Alzheimer's disease. They present these findings in the December 2009 issue of The American Journal of Pathology.

Alzheimer's disease is a degenerative, terminal form of dementia that affects over 35 million people world-wide. Oxidative stress, which occurs in the early stages of Alzheimer's disease, may modify molecules, resulting in loss or alteration of their function.

A precursor to nerve growth factor (pro-NGF) is expressed at high levels in Alzheimer's disease-affected individuals, and accumulation of pro-NGF may lead to neural cell death. Kichev et al showed that pro-NGF is modified in an Alzheimer's disease stage-dependent manner by oxidative stress and that modified pro-NGF blocked processing to mature NGF and led to neuronal cell death. Furthermore, injection of modified pro-NGF or pro-NGF derived from human Alzheimer's disease patients into mice resulted in cognitive and learning impairment, suggesting that modified pro-NGF may provide a novel pathogenic pathway for Alzheimer's disease.

Dr. Espinet's group suggests "that intra-cerebroventricular administration of AGE/ALEs modified pro-NGF to mice impairs learning tasks, thus reinforcing the idea that pro-NGF could have a relevant role in the ethiopathogenesis of the disease."


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The above post is reprinted from materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kichev et al. Cell Death and Learning Impairment in Mice Caused by in Vitro Modified Pro-NGF Can Be Related to Its Increased Oxidative Modifications in Alzheimer Disease. American Journal Of Pathology, 2009; DOI: 10.2353/ajpath.2009.090018

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American Journal of Pathology. "New cause for Alzheimer's disease?." ScienceDaily. ScienceDaily, 27 November 2009. <www.sciencedaily.com/releases/2009/11/091125151814.htm>.
American Journal of Pathology. (2009, November 27). New cause for Alzheimer's disease?. ScienceDaily. Retrieved July 4, 2015 from www.sciencedaily.com/releases/2009/11/091125151814.htm
American Journal of Pathology. "New cause for Alzheimer's disease?." ScienceDaily. www.sciencedaily.com/releases/2009/11/091125151814.htm (accessed July 4, 2015).

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