Featured Research

from universities, journals, and other organizations

Rodent smoke screen: Rat model shows tobacco smoke exposure induces brain changes indicative of nicotine dependence

Date:
December 8, 2009
Source:
Springer
Summary:
Rats passively exposed to tobacco smoke become dependent on nicotine, according to a new study. The findings of how rats' brains respond to exposure to tobacco smoke have implications for the study of the effects of tobacco smoke on the human brain and for future studies testing new treatments for tobacco addiction.

Rats passively exposed to tobacco smoke become dependent on nicotine, according to a new study by Dr. Adrie Bruijnzeel and colleagues from the University of Florida in the US. Their findings of how rats' brains respond to exposure to tobacco smoke have implications for the study of the effects of tobacco smoke on the human brain even from passive exposure to other smokers, and for future studies testing new treatments for tobacco addiction.

Related Articles


Their work has just been published online in Springer's journal Psychopharmacology.

Nicotine as well as many other compounds in tobacco smoke act together on the brain reward system and are addicting in smokers, but the effects of passive exposure have not been studied. In order to develop drug therapies for tobacco addiction, animal models that investigate the long-term effects of mere passive exposure to the addictive compounds in tobacco smoke are needed.

In a set of four experiments on male Wistar rats, Dr. Bruijnzeel and colleagues investigated whether rats exposed passively to tobacco smoke would become dependent on nicotine. They specifically looked at how the rats' brains responded to being exposed to tobacco smoke and whether the rats displayed withdrawal symptoms.

For all the experiments, freely moving rats were chronically exposed to tobacco smoke for a few hours per day. In the first experiment, the rats were fitted with an intracranial probe to measure the emotional aspects of tobacco withdrawal. The second experiment looked at whether being exposed to tobacco smoke decreased the rats' self-administration of nicotine. The third experiment investigated whether rats exposed to tobacco smoke were less motivated to eat. Finally, in the fourth experiment, the researchers looked specifically at the effects of tobacco smoke exposure on the brain's hippocampus, or grey matter -- the area of the brain most sensitive to smoke and nicotine-induced changes.

The rats exposed to tobacco smoke showed both affective and physical withdrawal signs, as well as nicotine-induced changes in the hippocampus, which demonstrates that passive exposure to tobacco smoke exposure leads to nicotine dependence.

The authors conclude: "These studies suggest that the rat tobacco smoke exposure model can be used to investigate the effects of tobacco smoke on the human brain and to evaluate the efficacy of novel treatments for tobacco addiction."


Story Source:

The above story is based on materials provided by Springer. Note: Materials may be edited for content and length.


Journal Reference:

  1. Small et al. Tobacco smoke exposure induces nicotine dependence in rats. Psychopharmacology, 2009; DOI: 10.1007/s00213-009-1716-z

Cite This Page:

Springer. "Rodent smoke screen: Rat model shows tobacco smoke exposure induces brain changes indicative of nicotine dependence." ScienceDaily. ScienceDaily, 8 December 2009. <www.sciencedaily.com/releases/2009/12/091208132536.htm>.
Springer. (2009, December 8). Rodent smoke screen: Rat model shows tobacco smoke exposure induces brain changes indicative of nicotine dependence. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2009/12/091208132536.htm
Springer. "Rodent smoke screen: Rat model shows tobacco smoke exposure induces brain changes indicative of nicotine dependence." ScienceDaily. www.sciencedaily.com/releases/2009/12/091208132536.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Former NFL Players Donate Brains to Science

Former NFL Players Donate Brains to Science

Reuters - US Online Video (Mar. 3, 2015) Super Bowl champions Sidney Rice and Steve Weatherford donate their brains, post-mortem, to scientific research into repetitive brain trauma. Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com
Alzheimer's Protein Plaque Found In 20-Year-Olds

Alzheimer's Protein Plaque Found In 20-Year-Olds

Newsy (Mar. 3, 2015) Researchers found an abnormal protein associated with Alzheimer&apos;s disease in the brains of 20-year-olds. Video provided by Newsy
Powered by NewsLook.com
This Nasal Treatment Could Help Ease Migraine Pain

This Nasal Treatment Could Help Ease Migraine Pain

Newsy (Mar. 2, 2015) Researchers gave lidocaine to 112 patients, and about 88 percent of the subjects said they needed less migraine-relief medicine the next day. Video provided by Newsy
Powered by NewsLook.com
How Facebook Use Can Lead To Depression

How Facebook Use Can Lead To Depression

Newsy (Mar. 1, 2015) Margaret Duffy of the University of Missouri talks about her study on the social network and the envy and depression that Facebook use can cause. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins