Featured Research

from universities, journals, and other organizations

Bone marrow cells may significantly reduce risk of second heart attack

Date:
December 10, 2009
Source:
American Heart Association
Summary:
After heart attack patients' arteries were cleared by reperfusion, progenitor cells, derived from the patients' own bone marrow, were infused into that artery. This reduced the risk of death or another heart attack. The finding also holds promise that bone marrow progenitor cells can reduce debilitating or fatal heart failure in heart attack survivors. Larger trials are needed to confirm the therapy before it becomes medical practice.

Cells from heart attack survivors' own bone marrow reduced the risk of death or another heart attack when they were infused into the affected artery after successful stent placement, according to research reported in the American Heart Association journal Circulation: Heart Failure.

Benefits found early in the Reinfusion of Enriched Progenitor Cells And Infarct Remodeling in Acute Myocardial Infarction (REPAIR-AMI) trial could last for at least two years, researchers said.

"More research is needed, but this gives us a hint of what might be possible with this new treatment -- prevention of another heart attack and of rehospitalization for heart failure, both life-threatening complications," said Birgit Assmus, M.D., first author of the study and assistant professor of cardiology at J.W. Goethe University in Frankfurt, Germany.

Researchers conducted the study at 17 centers in Germany and Switzerland. They randomized 101 heart attack survivors to receive a solution including progenitor cells from their own bone marrow. The other 103 patients received a placebo solution.

Progenitor cells, like stem cells, are early-stage cells. They are still able to differentiate into various types of certain adult cells -- but not exactly like a cellular "blank slate" seen with stem cells. Rather, progenitor cells are more specific than stem cells and are further along in the process towards forming the type of adult cell they will become.

Researchers infused cells or placebo into the artery that triggered patients' heart attacks three to seven days after undergoing reperfusion therapy. "The goal of this study was to prevent heart failure by enhancing new vessel growth and perfusion of the surviving tissue," Assmus said.

Among the study's results:

  • At two years, no patients from the bone marrow cell group had suffered a heart attack while seven patients from the placebo group had -- a statistically significant difference.
  • Compared with placebo patients, cell-infused patients were less likely to die (three vs. eight in placebo group), need new revascularizations (25 vs. 38), or be rehospitalized for heart failure (one vs. five).

"Large, randomized trials are urgently needed to assess the effects of progenitor-cell therapy in patients with heart attacks," Assmus said.

Co-authors are: Andreas Rolf, M.D.; Sandra Erbs, M.D.; Albrecht Elsässer, M.D.; Werner Haberbosch, M.D.; Rainer Hambrecht, M.D.; Harald Tillmanns, M.D.; Jiangtao Yu, M.D.; Roberto Corti, M.D.; Detlef G. Mathey, M.D.; Christian W. Hamm, M.D.; Tim Süselbeck, M.D.; Torsten Tonn, M.D., Stefanie Dimmeler, Ph.D.; Thorsten Dill, M.D.; Andreas M. Zeiher, M.D.; and Volker Schächinger, M.D.

Guidant and Eli Lilly funded the study.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Bone marrow cells may significantly reduce risk of second heart attack." ScienceDaily. ScienceDaily, 10 December 2009. <www.sciencedaily.com/releases/2009/12/091208162650.htm>.
American Heart Association. (2009, December 10). Bone marrow cells may significantly reduce risk of second heart attack. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2009/12/091208162650.htm
American Heart Association. "Bone marrow cells may significantly reduce risk of second heart attack." ScienceDaily. www.sciencedaily.com/releases/2009/12/091208162650.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) — West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) — A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) — Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) — Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins