Featured Research

from universities, journals, and other organizations

Bone marrow cells may significantly reduce risk of second heart attack

Date:
December 10, 2009
Source:
American Heart Association
Summary:
After heart attack patients' arteries were cleared by reperfusion, progenitor cells, derived from the patients' own bone marrow, were infused into that artery. This reduced the risk of death or another heart attack. The finding also holds promise that bone marrow progenitor cells can reduce debilitating or fatal heart failure in heart attack survivors. Larger trials are needed to confirm the therapy before it becomes medical practice.

Cells from heart attack survivors' own bone marrow reduced the risk of death or another heart attack when they were infused into the affected artery after successful stent placement, according to research reported in the American Heart Association journal Circulation: Heart Failure.

Benefits found early in the Reinfusion of Enriched Progenitor Cells And Infarct Remodeling in Acute Myocardial Infarction (REPAIR-AMI) trial could last for at least two years, researchers said.

"More research is needed, but this gives us a hint of what might be possible with this new treatment -- prevention of another heart attack and of rehospitalization for heart failure, both life-threatening complications," said Birgit Assmus, M.D., first author of the study and assistant professor of cardiology at J.W. Goethe University in Frankfurt, Germany.

Researchers conducted the study at 17 centers in Germany and Switzerland. They randomized 101 heart attack survivors to receive a solution including progenitor cells from their own bone marrow. The other 103 patients received a placebo solution.

Progenitor cells, like stem cells, are early-stage cells. They are still able to differentiate into various types of certain adult cells -- but not exactly like a cellular "blank slate" seen with stem cells. Rather, progenitor cells are more specific than stem cells and are further along in the process towards forming the type of adult cell they will become.

Researchers infused cells or placebo into the artery that triggered patients' heart attacks three to seven days after undergoing reperfusion therapy. "The goal of this study was to prevent heart failure by enhancing new vessel growth and perfusion of the surviving tissue," Assmus said.

Among the study's results:

  • At two years, no patients from the bone marrow cell group had suffered a heart attack while seven patients from the placebo group had -- a statistically significant difference.
  • Compared with placebo patients, cell-infused patients were less likely to die (three vs. eight in placebo group), need new revascularizations (25 vs. 38), or be rehospitalized for heart failure (one vs. five).

"Large, randomized trials are urgently needed to assess the effects of progenitor-cell therapy in patients with heart attacks," Assmus said.

Co-authors are: Andreas Rolf, M.D.; Sandra Erbs, M.D.; Albrecht Elsässer, M.D.; Werner Haberbosch, M.D.; Rainer Hambrecht, M.D.; Harald Tillmanns, M.D.; Jiangtao Yu, M.D.; Roberto Corti, M.D.; Detlef G. Mathey, M.D.; Christian W. Hamm, M.D.; Tim Süselbeck, M.D.; Torsten Tonn, M.D., Stefanie Dimmeler, Ph.D.; Thorsten Dill, M.D.; Andreas M. Zeiher, M.D.; and Volker Schächinger, M.D.

Guidant and Eli Lilly funded the study.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Bone marrow cells may significantly reduce risk of second heart attack." ScienceDaily. ScienceDaily, 10 December 2009. <www.sciencedaily.com/releases/2009/12/091208162650.htm>.
American Heart Association. (2009, December 10). Bone marrow cells may significantly reduce risk of second heart attack. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2009/12/091208162650.htm
American Heart Association. "Bone marrow cells may significantly reduce risk of second heart attack." ScienceDaily. www.sciencedaily.com/releases/2009/12/091208162650.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) — President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) — A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) — A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) — A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins