Featured Research

from universities, journals, and other organizations

Seeing is believing: visualizing blood clot formation inside blood vessels

Date:
December 21, 2009
Source:
Journal of Clinical Investigation
Summary:
Inappropriate activation of the blood clotting process inside a blood vessel results in the formation of a clot known as a thrombus. Thrombus formation in blood vessels in the brain and heart can lead to stroke and heart attack, respectively. Drugs that prevent blood clot formation reduce the risk of these conditions. A team of researchers has now identified a role for the protein Lnk in stabilizing thrombus formation in mice, suggesting that it might provide a therapeutic target to prevent thrombus formation.

Inappropriate activation of the blood clotting process inside a blood vessel results in the formation of a clot known as a thrombus. Thrombus formation in blood vessels in the brain and heart can lead to stroke and heart attack, respectively. Drugs that prevent blood clot formation reduce the risk of these conditions.

A team of researchers, at The University of Tokyo, Japan, and the International Medical Center of Japan, has now identified a role for the protein Lnk in stabilizing thrombus formation in mice, suggesting that it might provide a therapeutic target to prevent thrombus formation.

The research appears in the Journal of Clinical Investigation.

The team, led by Koji Eto and Satoshi Takaki, studied mice lacking Lnk and by imaging the process of thrombus formation in blood vessels found that Lnk played an essential role in stabilizing developing thrombi in blood vessels.

Further analysis revealed the key signaling pathway regulated by Lnk. As Lnk-deficient mice did not have a spontaneous bleeding problem, the authors suggest that targeting Lnk or other proteins in the pathway might provide therapeutic targets that provide less risk for bleeding than those targeted by conventional drugs.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hitoshi Takizawa, Satoshi Nishimura, Naoya Takayama, Atsushi Oda, Hidekazu Nishikii, Yohei Morita, Sei Kakinuma, Satoshi Yamazaki, Satoshi Okamura, Noriko Tamura, Shinya Goto, Akira Sawaguchi, Ichiro Manabe, Kiyoshi Takatsu, Hiromitsu Nakauchi, Satoshi Takaki and Koji Eto. Lnk regulates integrin alpha-IIb-beta-3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI39503

Cite This Page:

Journal of Clinical Investigation. "Seeing is believing: visualizing blood clot formation inside blood vessels." ScienceDaily. ScienceDaily, 21 December 2009. <www.sciencedaily.com/releases/2009/12/091221215648.htm>.
Journal of Clinical Investigation. (2009, December 21). Seeing is believing: visualizing blood clot formation inside blood vessels. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2009/12/091221215648.htm
Journal of Clinical Investigation. "Seeing is believing: visualizing blood clot formation inside blood vessels." ScienceDaily. www.sciencedaily.com/releases/2009/12/091221215648.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com
Amid Grave Ebola Estimates, US to Test Vaccine

Amid Grave Ebola Estimates, US to Test Vaccine

AP (Aug. 28, 2014) The National Institutes of Health will start the first human safety trials of an experimental Ebola vaccine next week, amid a grave estimate from the World Health Organization that Ebola cases in West Africa could top 20,000. (Aug. 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins