Featured Research

from universities, journals, and other organizations

Growing evidence suggests progesterone should be considered a treatment option for traumatic brain injuries

Date:
December 25, 2009
Source:
American College of Radiology / American Roentgen Ray Society
Summary:
Researchers recommend that progesterone, a naturally occurring hormone found in both males and females that can protect damaged cells in the central and peripheral nervous systems, be considered a viable treatment option for traumatic brain injuries.

Researchers at Emory University in Atlanta, GA, recommend that progesterone (PROG), a naturally occurring hormone found in both males and females that can protect damaged cells in the central and peripheral nervous systems, be considered a viable treatment option for traumatic brain injuries, according to a clinical perspective.

"Traumatic brain injury (TBI) is an important clinical problem in the United States and around the world," said Donald G. Stein, PhD, lead author of the paper. "TBI has received more attention recently because of its high incidence among combat casualties in Iraq and Afghanistan. Current Department of Defense statistics indicated that as many as 30 percent of wounded soldiers seen at Walter Reed Army Hospital have suffered a TBI, a finding that has stimulated government interest in developing a safe and effective treatment for this complex disorder," said Stein.

"Growing evidence indicates that post-injury administration of PROG in a variety of brain damage models can have beneficial effects, leading to substantial and sustained improvements in brain functionality. PROG given to both males and females can cross the blood-brain barrier and reduce edema (swelling) levels after TBI; in different models of cerebral ischemia (restriction of blood supply), significantly reduce the area of necrotic cell death and improve behavioral outcomes; and protect neurons distal to the injury that would normally die," said Stein.

PROG was recently tested in two phase 2 clinical trials for traumatic brain injury and will begin a phase 3 NIH sponsored trial soon.

"Given its relatively high safety profile, its ease of administration, its low cost and ready availability, PROG should be considered a viable treatment option -- especially because, in brain injury, so little else is currently available," said Stein.

This study appears in the January issue of the American Journal of Roentgenology.


Story Source:

The above story is based on materials provided by American College of Radiology / American Roentgen Ray Society. Note: Materials may be edited for content and length.


Cite This Page:

American College of Radiology / American Roentgen Ray Society. "Growing evidence suggests progesterone should be considered a treatment option for traumatic brain injuries." ScienceDaily. ScienceDaily, 25 December 2009. <www.sciencedaily.com/releases/2009/12/091222121759.htm>.
American College of Radiology / American Roentgen Ray Society. (2009, December 25). Growing evidence suggests progesterone should be considered a treatment option for traumatic brain injuries. ScienceDaily. Retrieved April 25, 2014 from www.sciencedaily.com/releases/2009/12/091222121759.htm
American College of Radiology / American Roentgen Ray Society. "Growing evidence suggests progesterone should be considered a treatment option for traumatic brain injuries." ScienceDaily. www.sciencedaily.com/releases/2009/12/091222121759.htm (accessed April 25, 2014).

Share This



More Mind & Brain News

Friday, April 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Marijuana Use Lead To Serious Heart Problems?

Could Marijuana Use Lead To Serious Heart Problems?

Newsy (Apr. 24, 2014) A new study says marijuana use could lead to serious heart-related complications. Video provided by Newsy
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
Do We Get Nicer With Age?

Do We Get Nicer With Age?

Newsy (Apr. 22, 2014) A recent report claims personality can change over time as we age, and usually that means becoming nicer and more emotionally stable. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins