Featured Research

from universities, journals, and other organizations

Weakened Plasmodium generates protective immunity

Date:
December 31, 2009
Source:
American Journal of Pathology
Summary:
Researchers have found that weakened Plasmodium elicits a protective immune response.

Dr. Andrea Crisanti and colleagues have found that weakened Plasmodium elicits a protective immune response.

They report their data in the January 2010 issue of the American Journal Pathology.

Malaria is a mosquito-borne disease that each year affects from 300-500 million people. Malaria is caused by infection with Plasmodium parasites, which go through a number of life cycle changes inside the host, increasing the challenges of malarial vaccine development.

Plasmepsin 4 is a digestive enzyme that is critical for Plasmodium growth and survival within the host red blood cells. Spaccapelo et al therefore examined Plasmodium parasites that lacked plasmepsin 4 expression for deficiencies in parasite growth and virulence. Although there was only a modest effect of plasmepsin 4 deficiency on Plasmodium growth and development within red blood cells, plasmepsin 4-null parasites were significantly less virulent than their wild-type counterparts. Infection with plasmepsin 4-deficient parasites, in contrast to infection with wild-type Plasmodium, did not induce cerebral complications. Furthermore, plasmepsin 4-null Plasmodium induced strong protective immune responses against secondary immunization with wild-type Plasmodium. Virulence-attenuated Plasmodium may therefore provide a model for assessing genetically-attenuated malarial vaccine candidates.

Dr. Crisanti and colleagues conclude that "it is possible, by engineered inactivation of parasite proteins, to generate attenuated blood stage parasites that are capable of inducing protective immunity against blood-stage infection. Such parasites should be powerful tools in elucidating parasite-derived factors that cause severe disease and should provide additional insight into factors that are required to induce protective immunity."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Spaccapelo R, Janse CJ, Caterbi S, Franke-Fayard B, Bonilla JA, Syphard LM, Di Cristina M, Dottorini T, Savarino A, Cassone A, Bistoni F, Waters AP, Dame JB, Crisanti A. Plasmepsin 4-Deficient Plasmodium berghei Are Virulence Attenuated and Induce Protective Immunity against Experimental Malaria. American Journal Of Pathology, 2010; 176 (1): 205 DOI: 10.2353/ajpath.2010.090504

Cite This Page:

American Journal of Pathology. "Weakened Plasmodium generates protective immunity." ScienceDaily. ScienceDaily, 31 December 2009. <www.sciencedaily.com/releases/2009/12/091230193211.htm>.
American Journal of Pathology. (2009, December 31). Weakened Plasmodium generates protective immunity. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2009/12/091230193211.htm
American Journal of Pathology. "Weakened Plasmodium generates protective immunity." ScienceDaily. www.sciencedaily.com/releases/2009/12/091230193211.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com
What's To Blame For Worst Ebola Outbreak In History?

What's To Blame For Worst Ebola Outbreak In History?

Newsy (July 27, 2014) A U.S. doctor has tested positive for the deadly Ebola virus, as the worst-ever outbreak continues to grow. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins