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Discovery may help baby boomers get buff: Free radicals damage mitochondria in muscle cells

Date:
January 7, 2010
Source:
Federation of American Societies for Experimental Biology
Summary:
If you're an aging baby boomer hoping for a buffer physique, there's hope. A team of scientists has made a significant discovery about the cause of age-related muscle atrophy that could lead to new drugs to halt this natural process.

If you're an aging baby boomer hoping for a buffer physique, there's hope. A team of American scientists from Texas and Michigan have made a significant discovery about the cause of age-related muscle atrophy that could lead to new drugs to halt this natural process.

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This research, available online the FASEB Journal, shows that free radicals, such as reactive oxygen species, damage mitochondria in muscle cells, leading to cell death and muscle atrophy. Now that scientists understand the cause of age-related muscle loss, they can begin to develop new drugs to halt the process.

"Age-related muscle atrophy in skeletal muscle is inevitable. However, we know it can be slowed down or delayed," said Holly Van Remmen, Ph.D., co-author of the study, from the Sam and Ann Barshop Institute for Longevity and Aging Studies at the University of Texas Health Science Center at San Antonio. "Our goal is to increase our understanding of the basic mechanisms underlying sarcopenia to gain insight that will help us to discover therapeutic interventions to slow or limit this process."

To make this discovery, Van Remmen and colleagues used mice that were genetically manipulated to prevent them from having a protective antioxidant (CuZnSOD). As a result of not being able to produce this antioxidant, the mice had very high levels of free radicals (reactive oxygen species) and lost muscle mass and function at a much faster rate than normal mice. Additionally, the muscles of the genetically modified mice were much smaller and weaker than those of normal mice. Scientists believe that these findings mimic effects of the normal aging process in humans, but at an accelerated rate.

"I don't expect to see baby boomers gracing the pages of body building magazines tomorrow. But this research is important because it identifies molecules responsible for the aging of our muscles: free radicals," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "Stop these from acting and we'll all look younger, stronger and fit at any age.


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Youngmok C. Jang, Michael S. Lustgarten, Yuhong Liu, Florian L. Muller, Arunabh Bhattacharya, Hanyu Liang, Adam B. Salmon, Susan V. Brooks, Lisa Larkin, Christopher R. Hayworth, Arlan Richardson, and Holly Van Remmen. Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration. The FASEB Journal, 2009; DOI: 10.1096/fj.09-146308

Cite This Page:

Federation of American Societies for Experimental Biology. "Discovery may help baby boomers get buff: Free radicals damage mitochondria in muscle cells." ScienceDaily. ScienceDaily, 7 January 2010. <www.sciencedaily.com/releases/2010/01/100104131307.htm>.
Federation of American Societies for Experimental Biology. (2010, January 7). Discovery may help baby boomers get buff: Free radicals damage mitochondria in muscle cells. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2010/01/100104131307.htm
Federation of American Societies for Experimental Biology. "Discovery may help baby boomers get buff: Free radicals damage mitochondria in muscle cells." ScienceDaily. www.sciencedaily.com/releases/2010/01/100104131307.htm (accessed October 25, 2014).

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