Featured Research

from universities, journals, and other organizations

Increased presence, severity of coronary artery plaques in HIV-infected men

Date:
January 8, 2010
Source:
Massachusetts General Hospital
Summary:
A new study has found that relatively young men with longstanding HIV infection and minimal cardiac risk factors had significantly more coronary atherosclerotic plaques -- some involving serious arterial blockage -- than did uninfected men with similar cardiovascular risk.

A Massachusetts General Hospital (MGH) study has found that relatively young men with longstanding HIV infection and minimal cardiac risk factors had significantly more coronary atherosclerotic plaques -- some involving serious arterial blockage -- than did uninfected men with similar cardiovascular risk.

Related Articles


The investigation appearing in the January 2010 issue of the journal AIDS is the first to use CT angiography to identify coronary artery plaques in HIV-infected participants.

"We were particularly surprised to find that several of the HIV patients -- none of whom had symptoms of heart disease -- had obstructive coronary artery disease, which was found in none of the controls," says Janet Lo, MD, of the Program in Nutritional Metabolism in the MGH Department of Medicine, who led the study. "It appears that both traditional and nontraditional risk factors are contributing to atherosclerotic disease in HIV-infected patients."

Several previous studies have found increased incidence of heart attacks and other cardiovascular events among HIV-infected patients, but it has not been clear whether that risk was attributable to recognized risk factors, such as elevated cholesterol and smoking, or to HIV-related immune system factors. The current study enrolled 110 men -- 78 with HIV infection and 32 uninfected controls -- without symptoms of cardiovascular disease. Participants ranged in age from 18 to 55, and both groups had low levels of traditional cardiovascular risk factors. The HIV-positive participants had longstanding infection, were generally healthy, and the great majority were receiving antiretroviral therapy.

After a detailed interview and physician examination, participants received both a standard cardiac CT scan using a 64-slice multidetector CT scanner and CT angiography. While the cardiac CT scan identifies calcium deposits in coronary arteries, CT angiography can also find non-calcified arterial plaques. The standard scans showed that the HIV-infected participants had levels of coronary calcium that, based on previous studies, would be expected in men who were six years older. The CT angiography revealed coronary atherosclerosis in 59 percent of the HIV-infected patients, compared with only 34 percent of controls. Five of the HIV-positive participants had critical coronary stenosis -- 70 percent or greater narrowing of one or more arterial segments -- something seen in none of the controls. Those participants were all referred to cardiologists for further evaluation and treatment.

"Our findings highlight the need to address reduction of cardiac risk factors early in the course of HIV disease and for caregivers to consider that even asymptomatic patients with longstanding HIV disease and minimal cardiac risk factors may have significant coronary artery disease," says Lo, who is an instructor in Medicine at Harvard Medical School. "We also found interesting associations between atherosclerosis levels and how long participants had been infected with HIV and with several inflammatory and immune factors. Future studies are needed to clarify the role of these nontraditional risk factors and find the best prevention and treatment strategies for these patients."

Steven Grinspoon, MD, director of the MGH Program in Nutritional Metabolism, is senior author of the AIDS report. Additional co-authors are Jeffrey Wei, Program in Nutritional Metabolism; and Sunny Abbara, MD, Leon Shturman, Anand Soni, Jose Rocha-Filho and Khurram Nasir, MGH Radiology. The study was supported by grants from the National Institutes of Health and Bristol Myers Squibb, Inc.


Story Source:

The above story is based on materials provided by Massachusetts General Hospital. Note: Materials may be edited for content and length.


Cite This Page:

Massachusetts General Hospital. "Increased presence, severity of coronary artery plaques in HIV-infected men." ScienceDaily. ScienceDaily, 8 January 2010. <www.sciencedaily.com/releases/2010/01/100107151659.htm>.
Massachusetts General Hospital. (2010, January 8). Increased presence, severity of coronary artery plaques in HIV-infected men. ScienceDaily. Retrieved February 28, 2015 from www.sciencedaily.com/releases/2010/01/100107151659.htm
Massachusetts General Hospital. "Increased presence, severity of coronary artery plaques in HIV-infected men." ScienceDaily. www.sciencedaily.com/releases/2010/01/100107151659.htm (accessed February 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, February 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Reuters - Innovations Video Online (Feb. 27, 2015) A dongle that plugs into a Smartphone mimics a lab-based blood test for HIV and syphilis and can detect the diseases in 15 minutes, say researchers. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Doctor Says Head Transplants Possible Within Two Years

Doctor Says Head Transplants Possible Within Two Years

Buzz60 (Feb. 27, 2015) An Italian doctor is saying he could stick someone&apos;s head onto someone else&apos;s body. Patrick Jones (@Patrick_E_Jones) reports. Video provided by Buzz60
Powered by NewsLook.com
How Your Dentist Could Help Screen You For Diabetes

How Your Dentist Could Help Screen You For Diabetes

Newsy (Feb. 27, 2015) A new study from researchers at New York University suggests dentists could soon use blood samples taken from patients&apos; mouths to test for diabetes. Video provided by Newsy
Powered by NewsLook.com
The Best Tips to Makeover Your Health

The Best Tips to Makeover Your Health

Buzz60 (Feb. 27, 2015) If you&apos;re looking to boost your health this season, there are a few quick and easy steps to prompt you for success. Krystin Goodwin (@Krystingoodwin) has the best tips to give your health a makeover this spring! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins