Featured Research

from universities, journals, and other organizations

New target discovered for treatment of cancer

Date:
January 11, 2010
Source:
Karolinska Institutet
Summary:
Researchers in Sweden have discovered a new way of blocking the formation of blood vessels and halting the growth of tumors in mice. A substance that exploits this mechanism could be developed into a new treatment for cancer.

Researchers at the Swedish medical university Karolinska Institutet have discovered a new way of blocking the formation of blood vessels and halting the growth of tumours in mice. A substance that exploits this mechanism could be developed into a new treatment for cancer.

For a cancer tumour to be able to grow larger than the size of a pea, the cancer cells need to stimulate the formation of new blood vessels that can supply the tumour with oxygen and nutrients, a process known as angiogenesis. A number of medicines which inhibit angiogenesis have been developed, but their effect has been limited, and there is still a major need for better medicines.

The new results concern a receptor on the surface of blood vessel cells called ALK1. When the researchers blocked ALK1 in tumours in mice, angiogenesis was inhibited and the tumours stopped growing. The ALK1 receptor is activated by a family of signalling proteins called TGF-β proteins that are very important for communication between different types of cell in a wide range of key processes in the body. The study indicates that two members of the TGF-β family (TGF-β and BMP9) work together to stimulate angiogenesis in tumours.

ALK1 was blocked partly by genetic means and partly using a pharmaceutical substance called RAP-041.

"We believe that RAP-041 could be used in combination with existing angiogenesis inhibitors to achieve the maximum effect," says associate professor Kristian Pietras, who led the study.

Clinical studies of ACE-041, the human equivalent of RAP-041, have already been begun in the USA by the company that holds the patent on the substance. One goal of these studies is to find out which types of tumour are most sensitive to ALK1 blockade.


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sara Cunha, Evangelia Pardali, Midory Thorikay, Charlotte Anderberg, Lukas Hawinkels, Marie-José Goumans, Jasbir Seehra, Carl-Henrik Heldin, Peterten Dijke, Kristian Pietras. Genetic and Pharmacological Targeting of Activin Receptor-like Kinase 1 Impairs Tumor Growth and Angiogenesis. The Journal of Experimental Medicine, Jan. 11, 2010

Cite This Page:

Karolinska Institutet. "New target discovered for treatment of cancer." ScienceDaily. ScienceDaily, 11 January 2010. <www.sciencedaily.com/releases/2010/01/100111112843.htm>.
Karolinska Institutet. (2010, January 11). New target discovered for treatment of cancer. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2010/01/100111112843.htm
Karolinska Institutet. "New target discovered for treatment of cancer." ScienceDaily. www.sciencedaily.com/releases/2010/01/100111112843.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) — A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) — A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) — Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) — The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins