Featured Research

from universities, journals, and other organizations

Novel growth pattern classification predictive of outcome in non-small cell lung cancer

Date:
January 18, 2010
Source:
American Association for Cancer Research
Summary:
Researchers have classified tumors into three growth patterns: destructive, alveolar and papillary. This is useful in patients undergoing operations.

Classifying non-small cell lung tumors by growth patterns had a strong predictive value for measures of survival.

Growth pattern refers to the tumor growth in relation to normal lung tissue and blood vessels within the tumor; tumors need these blood vessels to survive and scientists have been studying these patterns in an effort to individualize therapy.

In data presented at the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer, researchers classified tumors into three growth patterns: destructive, alveolar and papillary. In destructive patterns, the tumor makes its own microenvironment for further growth. In the alveolar pattern, the tumor uses the microenvironment of the lung to grow, and in the papillary pattern the normal lung tissue is preserved in the presence of a new microenvironment.

Peyman Sardari Nia, M.D., Ph.D., a postdoctoral fellow at the University of Antwerp in Belgium, and colleagues tested this classification to see if they had prognostic value in patients with non-small cell lung cancer.

"The current management, treatment and prognosis of lung cancer is treatment based on tumor-node-metastasis staging," said Sardari Nia. "Unfortunately, tumor node metastasis does not account for survival differences in the same stage and does not provide information about the biology of the tumor."

For this study, Sardari Nia and colleagues enrolled 432 patients who had a complete resection for primary non-small cell lung cancer. The researchers followed the patients for about 50 months. According to the classifications outlined, 71.1 percent had a destructive growth pattern, 13.9 percent had a papillary growth pattern and 15 percent had an alveolar growth pattern. These growth patterns were independent predictors for overall survival, disease-specific survival and disease-free survival.

Patients with an alveolar growth pattern had a 52 percent greater chance of a poor prognosis for overall survival and a nearly two-fold increased risk for poorer disease-specific survival and for disease-free survival.

"This biological classification provides explanations for survival differences at the same disease stage," said Sardari Nia. "Additionally, these growth patterns represent distinct biologic subtypes implying that different growth patterns might respond differently to the pallet of treatment modalities, paving the way for individualization of the patient's treatment."


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Novel growth pattern classification predictive of outcome in non-small cell lung cancer." ScienceDaily. ScienceDaily, 18 January 2010. <www.sciencedaily.com/releases/2010/01/100112165112.htm>.
American Association for Cancer Research. (2010, January 18). Novel growth pattern classification predictive of outcome in non-small cell lung cancer. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2010/01/100112165112.htm
American Association for Cancer Research. "Novel growth pattern classification predictive of outcome in non-small cell lung cancer." ScienceDaily. www.sciencedaily.com/releases/2010/01/100112165112.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins