Featured Research

from universities, journals, and other organizations

Promising candidates for malaria vaccine revealed

Date:
January 19, 2010
Source:
Walter and Eliza Hall Institute
Summary:
Researchers have uncovered a group of proteins that could form the basis of an effective vaccine against malaria. These new findings support the development of a vaccine against the blood-stage of malaria.

Dr. James Beeson, from the Walter and Eliza Hall Institute in Melbourne, Australia, has uncovered a group of proteins that could form the basis of an effective vaccine against malaria.
Credit: Walter and Eliza Hall Institute

Walter and Eliza Hall Institute researchers have uncovered a group of proteins that could form the basis of an effective vaccine against malaria.

These new findings support the development of a vaccine against the blood-stage of malaria.

Malaria is an infection of blood cells and is transmitted by mosquitoes. The most common form of malaria is caused by the parasite Plasmodium falciparum. Malaria parasites burrow into red blood cells by producing specific proteins. Once inside red blood cells, the parasites rapidly multiply, leading to massive numbers of parasites in the blood stream that can cause severe disease and death.

Dr James Beeson, Dr Freya Fowkes and Dr Jack Richards from the institute's Infection and Immunity division, along with Dr Julie Simpson from the University of Melbourne, have identified proteins produced by malaria parasites during the blood-stage that are effective at promoting immune responses that protect people from malaria illness.

Their findings are published in the international journal PLoS Medicine.

Drs Fowkes and Beeson identified these proteins by reviewing and synthesising data from numerous scientific studies that had looked at the relationship between antibodies produced by the human immune system in response to malaria infection and the ability of these antibodies to protect against malaria.

Dr Beeson said malaria caused by Plasmodium falciparum was a leading cause of death and disease globally, particularly among young children. "As well as presenting an enormous health burden, malaria also has a major impact on social and economic development in countries where the disease is endemic," Dr Beeson said. "Vaccines are urgently needed to reduce the burden of malaria and perhaps eventually eradicate the disease.

"A malaria vaccine that stimulates an efficient immune response against the proteins that malaria parasites use to burrow into red blood cells would stop the parasite from replicating and prevent severe illness."

Dr Fowkes said the review of existing studies had illustrated how little was known about blood-stage malaria proteins and their suitability for use in vaccine development.

"Only about six blood-stage malaria proteins have been well studied out of a potential 100 proteins," she said. "There is an urgent need for malaria researchers to better coordinate their research efforts on these proteins. This will take us one step closer to developing an effective vaccine."

The research was funded by the National Health and Medical Research Council of Australia and a Victorian Government Operational Infrastructure Support grant.


Story Source:

The above story is based on materials provided by Walter and Eliza Hall Institute. Note: Materials may be edited for content and length.


Cite This Page:

Walter and Eliza Hall Institute. "Promising candidates for malaria vaccine revealed." ScienceDaily. ScienceDaily, 19 January 2010. <www.sciencedaily.com/releases/2010/01/100118204041.htm>.
Walter and Eliza Hall Institute. (2010, January 19). Promising candidates for malaria vaccine revealed. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2010/01/100118204041.htm
Walter and Eliza Hall Institute. "Promising candidates for malaria vaccine revealed." ScienceDaily. www.sciencedaily.com/releases/2010/01/100118204041.htm (accessed August 23, 2014).

Share This




More Health & Medicine News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins