Featured Research

from universities, journals, and other organizations

Researchers find a treatment for deadly brain tumor

Date:
January 20, 2010
Source:
Lifespan
Summary:
New research has identified a treatment in animal models for glioblastomas -- deadly brain tumors which, once diagnosed, offer a poor prognosis and relatively short life expectancy. Using a synthetic form of a naturally-occurring hormone combined with chemotherapy, researchers were able to inhibit tumor growth and achieve a 25 percent cure rate.

New research at Rhode Island Hospital has identified a treatment in animal models for glioblastomas -- deadly brain tumors which, once diagnosed, offer a poor prognosis and relatively short life expectancy. Using a synthetic form of a naturally-occurring hormone combined with chemotherapy, researchers were able to inhibit tumor growth and achieve a 25 percent cure rate.

Related Articles


The study and their findings are published in the Journal of Oncology.

Led by Suzanne de la Monte, MD, MPH, of Rhode Island Hospital, researchers studied the effects of Thymosin Alpha 1 (Talpha1/thymalfasin), a synthetic form of the naturally occurring hormone Thymosin produced by the thymus gland. De la Monte, who is also a professor of neuroscience at The Warren Alpert Medical School of Brown University, says, "Our hypothesis was that the immune system basically needs a boost to kill the cancer cells. We know that Thymosin is currently being used in Europe to treat cancer, so we set out to see what effect this could have on glioblastomas."

What the investigators found is that when Talpha1 was used alone, the tumor continued to eventually grow. When they combined the Talpha1 with a common chemotherapeutic agent, there was a dramatic effect. De la Monte explains, "We looked at giving chemo plus Talpha1 as a sort of immune booster. What we found is that when you give Talpha1 and the chemo agent together, not only do you have a slower rate of tumor growth with cells being killed, but there have also been cures. We achieved a 25 percent cure rate in these animal models."

Co-investigator Jack Wands, MD, also a physician with University Medicine Foundation and a professor Alpert Medical School, says, "In this study we used a natural hormone that's been produced in the thymus gland, which by itself has no anti-tumor effect and in fact can be harmful in high doses. What's important in this study is that we have found with low to moderate doses in combination with a well-known chemotherapeutic agent, it has a striking ability to inhibit the growth of a glioblastoma in animal models."

The researchers went on to further investigate how the Talpha1 was achieving this response. What they discovered is that it sensitizes the tumor cells to the chemotherapeutic agent, giving the agent more of an impact upon the tumor than it would have on its own. De la Monte explains, "The thymic hormone is actually working to boost immune response and basically activates a killing of the tumor cells."

De la Monte says the next step is to bring this to a Phase I clinical trial. "You're talking about a disease where people are dead within months. There is no cure." Wands agrees and says, "Our pre-clinical studies have shown this striking effect and we believe the next step is to try this approach in patients with this devastating illness."

Other researchers involved in the study with de la Monte and Wands include Arno Sungarian, Deus Cielo, Prakash Sampath, Nathaniel Bowling and Peter Moskal from the departments of pathology, neurology and medicine at Rhode Island Hospital and The Warren Alpert Medical School of Brown University.

The study was funded through grants from the National Institutes of Health (NIH) and a training grant from the NIH's National Institute of Environmental Health Sciences (NIEHS).


Story Source:

The above story is based on materials provided by Lifespan. Note: Materials may be edited for content and length.


Cite This Page:

Lifespan. "Researchers find a treatment for deadly brain tumor." ScienceDaily. ScienceDaily, 20 January 2010. <www.sciencedaily.com/releases/2010/01/100119154713.htm>.
Lifespan. (2010, January 20). Researchers find a treatment for deadly brain tumor. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2010/01/100119154713.htm
Lifespan. "Researchers find a treatment for deadly brain tumor." ScienceDaily. www.sciencedaily.com/releases/2010/01/100119154713.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins