Featured Research

from universities, journals, and other organizations

Tree Shrew Offers Small-Animal Model of Hepatitis C Virus Infection

Date:
January 25, 2010
Source:
American Society for Microbiology
Summary:
Researchers from Japan suggest that the tree shrew may be a practical small-animal model for studying the progression of human hepatitis C virus (HCV) infection. This discovery would replace the need for rare and expensive studies using chimpanzees, currently the only validated animal model for HCV.

Researchers from Japan suggest that the tree shrew may be a practical small-animal model for studying the progression of human hepatitis C virus (HCV) infection. This discovery would replace the need for rare and expensive studies using chimpanzees, currently the only validated animal model for HCV.

They report their findings in the January 2010 issue of the Journal of Virology.

HCV is a highly potent viral infection that can ultimately lead to chronic hepatitis, liver steatosis, cirrhosis, and hepatocellular carcinoma. The current course of treatment against HCV includes interferon therapy (stimulating the processes within cells that slow the reproduction and growth of the virus) in conjunction with the antiviral drug ribavirin, however, the combination treatment is difficult for patients to endure and is often ineffective.

The tupaia (Tupaia belangeri), also known as a tree shrew, is a small non-primate mammal commonly found in certain regions of Southeast Asia. Previous studies have shown tupaias to be susceptible to a wide range of human-pathogenic viruses, including hepatitis B. In this study researchers inoculated tupaias with HCV and analyzed the progress of infection over a three-year period. Results showed mild hepatitis and intermittent viremia during the acute phase of infection, chronic hepatitis that worsened over time, and the detection of liver steatosis, cirrhotic nodules and the production of new tumors.

"These data suggest that the tupaia is a practical animal model for experimental studies of HCV infection," say the researchers. "Comparative studies of HCV infection in different species will help us to understand the basic mechanisms of persistent infection."


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Y. Amako, K. Tsukiyama-Kohara, A. Katsume, Y. Hirata, S. Sekiguchi, Y. Tobita, Y. Hayashi, T. Hishima, N. Funata, H. Yonekawa, M. Kohara. Pathogenesis of Hepatitis C Virus Infection in Tupaia belangeri. Journal of Virology, 2010; 84 (1): 303 DOI: 10.1128/JVI.01448-09

Cite This Page:

American Society for Microbiology. "Tree Shrew Offers Small-Animal Model of Hepatitis C Virus Infection." ScienceDaily. ScienceDaily, 25 January 2010. <www.sciencedaily.com/releases/2010/01/100121154300.htm>.
American Society for Microbiology. (2010, January 25). Tree Shrew Offers Small-Animal Model of Hepatitis C Virus Infection. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2010/01/100121154300.htm
American Society for Microbiology. "Tree Shrew Offers Small-Animal Model of Hepatitis C Virus Infection." ScienceDaily. www.sciencedaily.com/releases/2010/01/100121154300.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins