Featured Research

from universities, journals, and other organizations

Magnetic nanoparticles show promise for combating human cancer

Date:
February 4, 2010
Source:
Georgia Institute of Technology
Summary:
Scientists at Georgia Tech and the Ovarian Cancer Institute have further developed a potential new treatment against cancer that uses magnetic nanoparticles to attach to cancer cells, removing them from the body. The treatment, tested in mice in 2008, has now been tested using samples from human cancer patients.

Nanoparticles, in brown, attach themselves to cancer cells, in violet, from the human abdominal cavity.
Credit: Ken Scarberry/Georgia Tech

Scientists at Georgia Tech and the Ovarian Cancer Institute have further developed a potential new treatment against cancer that uses magnetic nanoparticles to attach to cancer cells, removing them from the body. The treatment, tested in mice in 2008, has now been tested using samples from human cancer patients. The results appear online in the journal Nanomedicine.

"We are primarily interested in developing an effective method to reduce the spread of ovarian cancer cells to other organs ," said John McDonald, professor at the the School of Biology at the Georgia Institute of Technology and chief research scientist at the Ovarian Cancer Institute.

The idea came to the research team from the work of Ken Scarberry, then a Ph.D. student at Tech. Scarberry originally conceived of the idea as a means of extracting viruses and virally infected cells. At his advisor's suggestion Scarberry began looking at how the system could work with cancer cells.

He published his first paper on the subject in the Journal of the American Chemical Society in July 2008. In that paper he and McDonald showed that by giving the cancer cells of the mice a fluorescent green tag and staining the magnetic nanoparticles red, they were able to apply a magnet and move the green cancer cells to the abdominal region.

Now McDonald and Scarberry, currently a post-doc in McDonald's lab, has showed that the magnetic technique works with human cancer cells.

"Often, the lethality of cancers is not attributed to the original tumor but to the establishment of distant tumors by cancer cells that exfoliate from the primary tumor," said Scarberry. "Circulating tumor cells can implant at distant sites and give rise to secondary tumors. Our technique is designed to filter the peritoneal fluid or blood and remove these free floating cancer cells, which should increase longevity by preventing the continued metastatic spread of the cancer."

In tests, they showed that their technique worked as well with at capturing cancer cells from human patient samples as it did previously in mice. The next step is to test how well the technique can increase survivorship in live animal models. If that goes well, they will then test it with humans.


Story Source:

The above story is based on materials provided by Georgia Institute of Technology. Note: Materials may be edited for content and length.


Journal References:

  1. Kenneth E. Scarberry, Erin B. Dickerson, Z. John Zhang, Benedict B. Benigno, John F. McDonald. Selective removal of ovarian cancer cells from human ascites fluid using magnetic nanoparticles. Nanomedicine Nanotechnology Biology and Medicine, 2009; DOI: 10.1016/j.nano.2009.11.003
  2. Kenneth E. Scarberry, Erin B. Dickerson, John F. McDonald and Z. John Zhang. Magnetic Nanoparticle−Peptide Conjugates for in Vitro and in Vivo Targeting and Extraction of Cancer Cells. Journal of the American Chemical Society, 2008; 130 (31): 10258 DOI: 10.1021/ja801969b

Cite This Page:

Georgia Institute of Technology. "Magnetic nanoparticles show promise for combating human cancer." ScienceDaily. ScienceDaily, 4 February 2010. <www.sciencedaily.com/releases/2010/02/100201101911.htm>.
Georgia Institute of Technology. (2010, February 4). Magnetic nanoparticles show promise for combating human cancer. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2010/02/100201101911.htm
Georgia Institute of Technology. "Magnetic nanoparticles show promise for combating human cancer." ScienceDaily. www.sciencedaily.com/releases/2010/02/100201101911.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins