Featured Research

from universities, journals, and other organizations

Benefit of HPV vaccination, frequent screening for women over 41 is likely to be low, study suggests

Date:
February 23, 2010
Source:
Journal of the National Cancer Institute
Summary:
The overall potential benefits of human papillomavirus (HPV) vaccinations or frequent HPV screenings for women over the age of 41 are low, concludes a new study. The study found that the rate of new infections preventable by vaccination declines with age. Furthermore, new infections among women at any age typically do not progress to cervical intraepithelial neoplasia grade 2 (CIN 2) or CIN 3, the precursors for cervical cancer.

The overall potential benefits of human papillomavirus (HPV) vaccinations or frequent HPV screenings for women over the age of 41 are low, concludes a new study published online February 15 in the Journal of the National Cancer Institute. The study found that the rate of new infections preventable by vaccination declines with age. Furthermore, new infections among women at any age typically do not progress to cervical intraepithelial neoplasia grade 2 (CIN 2) or CIN 3, the precursors for cervical cancer.

Related Articles


This study was undertaken because researchers wanted to examine whether women's age and the duration of carcinogenic HPV infections influenced subsequent persistence of infection and risk of CIN 2 or worse disease.

Ana Cecilia Rodríguez, M.D., of the Proyecto Epidemiológico Guanacaste, Fundación INCIENSA, in San José, Costa Rica, and colleagues screened over 9,000 women in Costa Rica aged 18 to 97 years. Those with CIN 2 or worse disease at enrollment were treated and not followed further. Among the remaining participants, those at low risk of CIN 2 or worse were rescreened at 5-7 years (passively followed), whereas higher-risk participants and subsets of low-risk women and initially sexually non-active women were rescreened annually or semiannually (actively followed) for up to 7 years.

Most of the CIN 2 or worse disease diagnosed during the study period was associated with persistent carcinogenic HPV infections that were prevalent, or already present at the time of initial testing.

The vast majority of newly detected carcinogenic HPV infections did not persist and did not lead to CIN 2 or worse disease during the study period, regardless of age. The rate of newly detected carcinogenic HPV infections declined with increasing age and ranged from 35 percent in women aged 18-25 years to 13.5 percent in women aged 42 years and older.

"Understanding the relevance of the concept of duration of infection can improve cervical cancer prevention strategies that integrate prophylactic vaccination with HPV screening," the authors write. "For example, evidence that newly detected infections in older women do not harbor a higher risk of persistence or CIN 2 [or worse disease] than in younger women and that older women acquire fewer new infections indicates that the possible benefit of vaccinating older women is much reduced..."

Study limitations: The most important conclusion that newly-detected HPV infections typically do not progress to CIN2 or worse at any age might not hold beyond the 7 years of follow-up in this study.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "Benefit of HPV vaccination, frequent screening for women over 41 is likely to be low, study suggests." ScienceDaily. ScienceDaily, 23 February 2010. <www.sciencedaily.com/releases/2010/02/100215173958.htm>.
Journal of the National Cancer Institute. (2010, February 23). Benefit of HPV vaccination, frequent screening for women over 41 is likely to be low, study suggests. ScienceDaily. Retrieved March 4, 2015 from www.sciencedaily.com/releases/2010/02/100215173958.htm
Journal of the National Cancer Institute. "Benefit of HPV vaccination, frequent screening for women over 41 is likely to be low, study suggests." ScienceDaily. www.sciencedaily.com/releases/2010/02/100215173958.htm (accessed March 4, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, March 4, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mom Triumphs Over Tragedy, Helps Other Families

Mom Triumphs Over Tragedy, Helps Other Families

AP (Mar. 3, 2015) — After her son, Dax, died from a rare form of leukemia, Julie Locke decided to give back to the doctors at St. Jude Children&apos;s Research Hospital who tried to save his life. She raised $1.6M to help other patients and their families. (March 3) Video provided by AP
Powered by NewsLook.com
Looted and Leaking, South Sudan's Oil Wells Pose Health Risk

Looted and Leaking, South Sudan's Oil Wells Pose Health Risk

AFP (Mar. 3, 2015) — Thick black puddles and a looted, leaking ruin are all that remain of the Thar Jath oil treatment facility, once a crucial part of South Sudan&apos;s mainstay industry. Duration: 01:13 Video provided by AFP
Powered by NewsLook.com
Woman Convicted of Poisoning Son

Woman Convicted of Poisoning Son

AP (Mar. 3, 2015) — A woman who blogged for years about her son&apos;s constant health woes was convicted Monday of poisoning him to death by force-feeding heavy concentrations of sodium through his stomach tube. (March 3) Video provided by AP
Powered by NewsLook.com
Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) — Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:  

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile iPhone Android Web
          Follow Facebook Twitter Google+
          Subscribe RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins