Featured Research

from universities, journals, and other organizations

ALDH associated with worse overall survival in patients with pancreatic adenocarcinoma

Date:
February 17, 2010
Source:
Journal of the National Cancer Institute
Summary:
Expression of aldehyde dehydrogenase (ALDH) in pancreatic adenocarcinoma is associated with worse overall survival in patients who have undergone resection for early-stage disease, according to a new study.

Expression of aldehyde dehydrogenase (ALDH) in pancreatic adenocarcinoma is associated with worse overall survival in patients who have undergone resection for early-stage disease, according to a new study published online February 17 in the Journal of the National Cancer Institute.

Related Articles


ALDH activity characterizes normal stem cells and cancer stem cells (CSCs) in several human malignancies, including pancreatic adenocarcinoma; however, the clinical significance of ALDH-expressing cancer stem cells is unclear.

William Matsui, M.D., of the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, in Baltimore, and colleagues analyzed ALHD expression by immunohistochemisty in 269 primary surgical specimens of pancreatic adenocarcinoma and its association with survival. Reverse transcription -- polymerase chain reaction and in vitro cell invasion assays were used to examine mesenchymal features (the ability to differentiate into a variety of cell types) and the invasive potential of ADLH-positive pancreatic cancer cells relative to the bulk cell population.

ALDH-positive tumor cells were detected in 90 of the 269 primary surgical specimens, and their presence was associated with worse survival (median survival for patients with ALDH-positive tumors was 14 months vs 18 months for patients with ALDH-negative tumors). ALDH-positive cells were approximately five- to 11-fold more likely to proliferate in vitro and in vivo compared with unsorted or ALHD-negative cells. These cells also expressed genes consistent with a mesenchymal state and had in vitro migratory and invasive potentials that were threefold greater than those of unsorted cells.

"These results provide evidence for the clinical relevance of CSCs in pancreatic adenocarcinoma and may explain how the detection of these cells in primary tumors may result in shortened overall survival," the authors write.

Study limitations: The clinical conclusions about ALDH expression as a prognostic marker in pancreatic adenocarcinoma were based on retrospective analyses and were not independently validated. Differences in tumorigenic capacity between distinct cell populations in immunodeficient mice are limited by the inherent limitations of a xenotransplantation assay.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "ALDH associated with worse overall survival in patients with pancreatic adenocarcinoma." ScienceDaily. ScienceDaily, 17 February 2010. <www.sciencedaily.com/releases/2010/02/100217171913.htm>.
Journal of the National Cancer Institute. (2010, February 17). ALDH associated with worse overall survival in patients with pancreatic adenocarcinoma. ScienceDaily. Retrieved March 4, 2015 from www.sciencedaily.com/releases/2010/02/100217171913.htm
Journal of the National Cancer Institute. "ALDH associated with worse overall survival in patients with pancreatic adenocarcinoma." ScienceDaily. www.sciencedaily.com/releases/2010/02/100217171913.htm (accessed March 4, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, March 4, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Adults Only Get The Flu Twice A Decade, Researchers Say

Adults Only Get The Flu Twice A Decade, Researchers Say

Newsy (Mar. 4, 2015) Researchers found adults only get the flu about once every five years. Scientists analyzed how a person&apos;s immunity builds up over time as well. Video provided by Newsy
Powered by NewsLook.com
New Hormone Could Protect Against Diabetes And Weight Gain

New Hormone Could Protect Against Diabetes And Weight Gain

Newsy (Mar. 4, 2015) A newly discovered hormone mimics the effects of exercise, protecting against diabetes and weight gain. Video provided by Newsy
Powered by NewsLook.com
Mount Everest Has a Poop Problem

Mount Everest Has a Poop Problem

Buzz60 (Mar. 4, 2015) With no bathrooms to use, climbers of Mount Everest have been leaving human waste on the mountain for years, and it&apos;s becoming a health issue. Mike Janela (@mikejanela) has more. Video provided by Buzz60
Powered by NewsLook.com
The Best Tips to 'Skinny' Your Home

The Best Tips to 'Skinny' Your Home

Buzz60 (Mar. 4, 2015) If you&apos;re looking to reach your health goals this season, there are a few simple tips to help you spring clean your space and improve your nutrition. Krystin Goodwin (@krystingoodwin) has the skinny on keeping a healthy home. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins