Featured Research

from universities, journals, and other organizations

Single-dose H5N1 vaccine safe and effective in adults and elderly

Date:
February 26, 2010
Source:
American Society for Microbiology
Summary:
Researchers from Hungary and the UK have developed a single-dose H5N1 influenza vaccine that induces a protective level of immunity against infection in healthy adult and elderly volunteers. The vaccine is the first single-dose regimen to be tested in elderly subjects and it fulfills all European Union and U.S. licensing criteria offering a promising influenza A virus vaccine candidate.

Researchers from Hungary and the UK have developed a single-dose H5N1 influenza vaccine that induces a protective level of immunity against infection in healthy adult and elderly volunteers. The vaccine is the first single-dose regimen to be tested in elderly subjects and it fulfills all European Union and U.S. licensing criteria offering a promising influenza A virus vaccine candidate.

Related Articles


They report their findings in the February 2010 issue of the Journal of Virology.

New cases of human H5N1 infection continue to emerge worldwide resulting in severe illness and high fatality rates. In the case of a pandemic, vaccination is likely to be the most effective approach toward minimizing illness and death. Already a variety of candidate vaccines are being tested, however, most require two-dose regimens to be effective.

In the study researchers developed a whole-virion, inactivated, adjuvanted H5N1 vaccine and tested its safety and efficacy in healthy adult and elderly volunteers. Subjects were randomly assigned to receive one or two doses of 3.5 μg of the vaccine or one dose of 6 or 12 μg of the vaccine. Safety and side effects were monitored following vaccination and blood samples were collected to determine immune response. Occasional injection site pain, fever and fatigue were the only reported side effects and while antibody responses were observed in all the subjects, single doses of 6 μg or more fulfilled the European Union and U.S. licensing criteria.

"We found that the present vaccine is safe and immunogenic in healthy adult and elderly subjects and requires low doses and, unlike any other H5N1 vaccines, only one injection to trigger immune responses which comply with licensing criteria," say the researchers.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Z. Vajo, J. Wood, L. Kosa, I. Szilvasy, G. Paragh, Z. Pauliny, K. Bartha, I. Visontay, A. Kis, I. Jankovics. A Single-Dose Influenza A (H5N1) Vaccine Safe and Immunogenic in Adult and Elderly Patients: an Approach to Pandemic Vaccine Development. Journal of Virology, 2010; 84 (3): 1237 DOI: 10.1128/JVI.01894-09

Cite This Page:

American Society for Microbiology. "Single-dose H5N1 vaccine safe and effective in adults and elderly." ScienceDaily. ScienceDaily, 26 February 2010. <www.sciencedaily.com/releases/2010/02/100224171933.htm>.
American Society for Microbiology. (2010, February 26). Single-dose H5N1 vaccine safe and effective in adults and elderly. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2010/02/100224171933.htm
American Society for Microbiology. "Single-dose H5N1 vaccine safe and effective in adults and elderly." ScienceDaily. www.sciencedaily.com/releases/2010/02/100224171933.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins