Featured Research

from universities, journals, and other organizations

Gene-based stem cell therapy specifically removes cell receptor that attracts HIV

Date:
February 28, 2010
Source:
University of California - Los Angeles
Summary:
Researchers have successfully removed CCR5 -- a cell receptor to which HIV-1 binds for infection but which the human body does not need -- from human cells. Individuals who naturally lack the CCR5 receptor have been found to be essentially resistant to HIV.

UCLA AIDS Institute researchers successfully removed CCR5 -- a cell receptor to which HIV-1 binds for infection but which the human body does not need -- from human cells. Individuals who naturally lack the CCR5 receptor have been found to be essentially resistant to HIV.

Related Articles


Using a humanized mouse model, the researchers transplanted a small RNA molecule known as short hairpin RNA (shRNA), which induced RNA interference into human blood stem cells to inhibit the expression of CCR5 in human immune cells.

The findings provide evidence that this strategy can be an effective way to treat HIV-infected individuals, by prompting long-term and stable reduction of CCR5.

Saki Shimizu, Patrick Hong, Balamurugan Arumugam, Lauren Pokomo, Joshua Boyer, Naoya Koizumi, Panyamol Kittipongdaja, Angela Chen, Greg Bristol, Zoran Galic, Jerome A. Zack, Otto Yang, Irvin S.Y. Chen, Benhur Lee and Dong Sung An, all of UCLA.

Blood, Journal of the American Society of Hematology

The research was funded by a Rheumatology Fellowship Training grant, the UCLA AIDS Institute, the UCLA Center for AIDS Research, the National Institute of Allergy and Infectious Diseases, the National Heart, Lung and Blood Institute, and the National Cancer Institute.


Story Source:

The above story is based on materials provided by University of California - Los Angeles. The original article was written by Enrique Rivero. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Los Angeles. "Gene-based stem cell therapy specifically removes cell receptor that attracts HIV." ScienceDaily. ScienceDaily, 28 February 2010. <www.sciencedaily.com/releases/2010/02/100225164859.htm>.
University of California - Los Angeles. (2010, February 28). Gene-based stem cell therapy specifically removes cell receptor that attracts HIV. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2010/02/100225164859.htm
University of California - Los Angeles. "Gene-based stem cell therapy specifically removes cell receptor that attracts HIV." ScienceDaily. www.sciencedaily.com/releases/2010/02/100225164859.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins