Featured Research

from universities, journals, and other organizations

Vitamin D deficiency likely among some kidney disease patients starting dialysis

Date:
February 25, 2010
Source:
American Society of Nephrology
Summary:
Vitamin D deficiency is almost universal among kidney disease patients who have low blood protein levels and who start dialysis during the winter, according to a new study. The research identifies a group of patients who are at extremely high risk of being deficient in vitamin D and provides some clues as to why the deficiency occurs in these individuals.

Vitamin D deficiency is almost universal among kidney disease patients who have low blood protein levels and who start dialysis during the winter, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The research identifies a group of patients who are at extremely high risk of being deficient in vitamin D and provides some clues as to why the deficiency occurs in these individuals.

Vitamin D deficiency is common in patients with end-stage renal disease (ESRD) on dialysis, but it's not clear which patients are at increased risk. Ishir Bhan, MD, MPH (Massachusetts General Hospital), and his colleagues sought to determine whether routinely measured clinical and demographic characteristics could identify dialysis patients who have a high risk of vitamin D deficiency. The researchers analyzed data from 908 patients in the Accelerated Mortality on Renal Replacement (ArMORR) cohort, a nationally representative group of U.S. dialysis patients. Data from 60% of the patients were used to find potential predictors of vitamin D deficiency, while data from the other 40% of patients were used to validate the predictors.

The investigators found that 79% of the study population was vitamin D deficient. Black race, female sex, winter season, and low blood levels of the protein albumin (≤ 3.1 g/dL) were the strongest predictors of vitamin D deficiency. In the validation set, the presence of low blood albumin levels and winter season increased the likelihood of vitamin D deficiency in black females (from 90% to 100%), black males (from 85% to 100%), white females (from 82% to 94%), and white males (from 66% to 92%).

"This research identifies risk factors for nutritional vitamin D deficiency in the dialysis population and may provide clues to its biology in this population," said Dr. Bhan. One interpretation of the finding that low blood albumin levels were associated with deficiency is that at-risk patients leak large amounts of protein in their urine. The investigators suspect that vitamin D binding protein, which transports the vitamin through the blood, may also be lost through the urine. Its loss could lead to the loss of vitamin D as well. In addition, while previous studies have suggested that patients on dialysis have an impaired ability to generate vitamin D from sun exposure, these findings emphasize that skin-based production of the vitamin is likely to be important in patients with ESRD.

Study co-authors include Sherri-Ann Burnett-Bowie, MD, MPH, Jun Ye, PhD, Ravi Thadhani, MD MPH (Massachusetts General Hospital), and Marcello Tonelli, MD (University of Alberta, Edmonton, Canada).

Dr. Thadhani has received research support from Abbott Laboratories.


Story Source:

The above story is based on materials provided by American Society of Nephrology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Clinical Measures Identify Vitamin D Deficiency in Dialysis. Clinical Journal of the American Society Nephrology, February 25, 2010 DOI: 10.2215/CJN.06440909

Cite This Page:

American Society of Nephrology. "Vitamin D deficiency likely among some kidney disease patients starting dialysis." ScienceDaily. ScienceDaily, 25 February 2010. <www.sciencedaily.com/releases/2010/02/100225172330.htm>.
American Society of Nephrology. (2010, February 25). Vitamin D deficiency likely among some kidney disease patients starting dialysis. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2010/02/100225172330.htm
American Society of Nephrology. "Vitamin D deficiency likely among some kidney disease patients starting dialysis." ScienceDaily. www.sciencedaily.com/releases/2010/02/100225172330.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
101-Year-Old Working Man Has All The Advice You Need

101-Year-Old Working Man Has All The Advice You Need

Newsy (Aug. 19, 2014) Herman Goldman has worked at the same lighting store for almost 75 years. Find out his secrets to a happy, productive life. Video provided by Newsy
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
American Ebola Patient Apparently Improving, Outbreak Is Not

American Ebola Patient Apparently Improving, Outbreak Is Not

Newsy (Aug. 19, 2014) Nancy Writebol, an American missionary who contracted Ebola, is apparently getting better, according to her husband. The outbreak, however, is not. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins