New! Sign up for our free email newsletter.
Science News
from research organizations

Neurobiology: Common mechanism for more than 50% of cases of hereditary spastic paraplegia

Date:
March 1, 2010
Source:
Journal of Clinical Investigation
Summary:
Hereditary spastic paraplegia (HSP) is the name given to a group of inherited neurological disorders characterized by progressive stiffness or tightness of the muscles (spasticity) in the lower limbs. Although mutations at over 40 genetic sites have been shown to cause HSP, more than 50% of HSP cases are caused by mutations in one of just three genes: SPG3A, which makes the protein atlastin-1; SPG31, which makes the protein REEP1; and SPG4, which makes the protein spastin.
Share:
FULL STORY

Hereditary spastic paraplegia (HSP) is the name given to a group of inherited neurological disorders characterized by progressive stiffness or tightness of the muscles (spasticity) in the lower limbs. Although mutations at over 40 genetic sites have been shown to cause HSP, more than 50% of HSP cases are caused by mutations in one of just three genes: SPG3A, which makes the protein atlastin-1; SPG31, which makes the protein REEP1; and SPG4, which makes the protein spastin.

New research, performed by Craig Blackstone and colleagues, at the NIH, Bethesda, has now determined that a single mechanism is likely to underlie HSP caused by mutations in any of these three genes.

Specifically, the in vitro data generated by Blackstone and colleagues indicate that atlastin-1, spastin, and REEP1 interact within a cellular compartment known as the tubular ER membrane in nerve cells that connect the cerebral cortex of the brain and the spinal cord to coordinate ER shaping and ER interactions with a cellular structure known as the microtubule cytoskeleton and that defects in these processes underlie the more than 50% of HSP cases caused by mutations in SPG3A, SPG31, and SPG4.

The research appears in the Journal of Clinical Investigation.


Story Source:

Materials provided by Journal of Clinical Investigation. Note: Content may be edited for style and length.


Journal Reference:

  1. seong H. Park, Peng-Peng Zhu, Rell L. Parker, and Craig Blackstone. Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI40979

Cite This Page:

Journal of Clinical Investigation. "Neurobiology: Common mechanism for more than 50% of cases of hereditary spastic paraplegia." ScienceDaily. ScienceDaily, 1 March 2010. <www.sciencedaily.com/releases/2010/03/100301212152.htm>.
Journal of Clinical Investigation. (2010, March 1). Neurobiology: Common mechanism for more than 50% of cases of hereditary spastic paraplegia. ScienceDaily. Retrieved March 28, 2024 from www.sciencedaily.com/releases/2010/03/100301212152.htm
Journal of Clinical Investigation. "Neurobiology: Common mechanism for more than 50% of cases of hereditary spastic paraplegia." ScienceDaily. www.sciencedaily.com/releases/2010/03/100301212152.htm (accessed March 28, 2024).

Explore More

from ScienceDaily

RELATED STORIES