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Anti-hypertensive drugs to enhance esophageal contraction

Date:
March 5, 2010
Source:
World Journal of Gastroenterology
Summary:
A research team from Japan clarified the effects of three different types of anti-hypertensive drugs on the three different segments of esophageal body contractions using a recently developed high-resolution manometric system. Their study showed that among the anti-hypertensive drugs tested, atenolol enhanced esophageal motor activity, which was in contrast to nifedipine.

Nifedipine, a calcium-channel blocker, was shown to decrease lower esophageal sphincter pressure and increase esophageal acid exposure time, while atenolol, a b1 blocker, was shown to inhibit relaxation of the smooth muscle of the esophagus. However, the influence of these anti-hypertensive drugs on the segment of esophageal body contraction using high-resolution manometry was not fully investigated.

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A research team from Japan observed esophageal body contraction using high-resolution manometry with 36 intraruminal transducers. Their study was published on February 28, 2010 in the World Journal of Gastroenterology.

Their research demonstrated that atenolol increased lower esophageal sphincter (LES) pressure and the amplitude of peristaltic contractions, in the middle and lower segments of the esophageal body. On the other hand, nifedipine decreased LES pressure and the amplitude of peristaltic contractions in the esophageal body.

Their results suggested that a regular administration of nifedipine for treatment of hypertension might be a risk factor for the future occurrence of gastro-esophageal reflux disease (GERD). Atenolol-induced alterations of esophageal motor activity might prevent the development of GERD.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yoshida K, Furuta K, Adachi K, Ohara S, Morita T, Tanimura T, Nakata S, Miki M, Koshino K, Kinoshita Y. Effects of anti-hypertensive drugs on esophageal body contraction. World Journal of Gastroenterology, 2010; 16 (8): 987 DOI: 10.3748/wjg.v16.i8.987

Cite This Page:

World Journal of Gastroenterology. "Anti-hypertensive drugs to enhance esophageal contraction." ScienceDaily. ScienceDaily, 5 March 2010. <www.sciencedaily.com/releases/2010/03/100305112211.htm>.
World Journal of Gastroenterology. (2010, March 5). Anti-hypertensive drugs to enhance esophageal contraction. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2010/03/100305112211.htm
World Journal of Gastroenterology. "Anti-hypertensive drugs to enhance esophageal contraction." ScienceDaily. www.sciencedaily.com/releases/2010/03/100305112211.htm (accessed November 24, 2014).

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