Featured Research

from universities, journals, and other organizations

Soluble factor IFN-beta represses tumor growth

Date:
March 8, 2010
Source:
Journal of Clinical Investigation
Summary:
Tumors that grow to a certain size need to form new blood vessels if they are to continue to grow and spread to other sites. Although the molecules and signaling pathways that control this new blood vessel growth are potential therapeutic targets, they have not been completely defined. However, researchers have now identified the soluble factor IFN-beta as a natural inhibitor of tumor blood vessel growth that limits tumor growth in mice.

Tumors that grow to a certain size need to form new blood vessels if they are to acquire the oxygen and nutrients that are essential for their continued growth and spread to other sites. Although the molecules and signaling pathways that control this new blood vessel growth are potential targets for the treatment of cancer, they have not been completely defined.

Using mouse models of cancer, Jadwiga Jablonska and colleagues, at the Helmholtz Centre for Infection Research, Germany, have now identified the soluble factor IFN-beta as a natural inhibitor of tumor blood vessel growth that limits tumor growth and works by repressing in tumor-infiltrating immune cells known as neutrophils the expression of genes responsible for promoting new blood vessel growth.

These results provide a potential explanation as to why IFN therapy is beneficial during the early stages of cancer development.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jadwiga Jablonska, Sara Leschner, Kathrin Westphal, Stefan Lienenklaus and Siegfried Weiss. Neutrophils responsive to endogenous IFN-%u03B2 regulate tumor angiogenesis and growth in a mouse tumor model. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI37223

Cite This Page:

Journal of Clinical Investigation. "Soluble factor IFN-beta represses tumor growth." ScienceDaily. ScienceDaily, 8 March 2010. <www.sciencedaily.com/releases/2010/03/100308170949.htm>.
Journal of Clinical Investigation. (2010, March 8). Soluble factor IFN-beta represses tumor growth. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2010/03/100308170949.htm
Journal of Clinical Investigation. "Soluble factor IFN-beta represses tumor growth." ScienceDaily. www.sciencedaily.com/releases/2010/03/100308170949.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins