Featured Research

from universities, journals, and other organizations

Donating kidney does not appear to significantly increase long-term risk of death

Date:
March 15, 2010
Source:
JAMA and Archives Journals
Summary:
An analysis of outcomes for live kidney donors in the US over a 15 year period finds they have similar long-term survival rates compared to healthy individuals who were not kidney donors, according to a new study.

An analysis of outcomes for live kidney donors in the U.S. over a 15 year period finds they have similar long-term survival rates compared to healthy individuals who were not kidney donors, according to a study in the March 10 issue of JAMA.

Many patients with end-stage renal (kidney) disease are turning to live donor kidney transplantation to improve survival and quality of life because of the shortage of organs available from the deceased donor pool. "Although many healthy adults are eager and willing to accept the risk of donor nephrectomy [surgical removal of a kidney] to help their loved ones, the responsibility lies within the medical community to quantify these risks as best as possible and to make this information available to those considering donation," the authors write. More than 6,000 healthy U.S. individuals every year undergo nephrectomy for the purposes of live donation; however, safety remains in question because of the limited generalizability of previous studies, according to background information in the article.

Dorry L. Segev, M.D., Ph.D., of the Johns Hopkins University School of Medicine, Baltimore, and colleagues examined the outcomes of live kidney donors (80,347) in the United States between April 1, 1994, and March 31, 2009, who were drawn from a mandated national registry. Median (midpoint) follow-up was 6.3 years. A matched group was drawn from 9,364 participants of the third National Health and Nutrition Examination Survey (NHANES III).

During the study period, there were 25 deaths within 90 days of live kidney donation, with the risk of death being 3.1 per 10,000 donors, compared to a rate of death for the NHANES III matched group of 0.4 per 10,000 persons. By 1 year following nephrectomy, risk of death in the matched group was similar to the live donor group, likely representing deaths attributable to comorbidity (co-existing illnesses) rather than death because of the surgery. The researchers found that long-term mortality was similar or lower for live kidney donors than for the matched NHANES III group throughout the 12-year period of follow-up (5-year follow-up, 0.4 percent vs. 0.9 percent; 12-year follow-up, 1.5 percent vs. 2.9 percent, respectively).

"Surgical mortality did not change during the 15-year period, despite differences in surgical practice and donor selection. Men had a statistically significantly higher surgical mortality than women did, as did black individuals vs. white and Hispanic individuals," the authors write. Donors with hypertension also had a statistically significantly higher surgical mortality than did donors without hypertension.

"Regardless of what physiologic changes might occur in a healthy adult after kidney donation, our findings of similar long-term survival between donors and healthy comparison patients suggest that these physiologic changes do not result in premature death. Although additional studies are clearly needed to better understand the physiologic changes after kidney donation, the current practice of live kidney donation should continue to be considered a reasonable and safe modality for addressing the profound shortage in deceased donor organs," the authors conclude.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Dorry L. Segev; Abimereki D. Muzaale; Brian S. Caffo; Shruti H. Mehta; Andrew L. Singer; Sarah E. Taranto; Maureen A. McBride; Robert A. Montgomery. Perioperative Mortality and Long-term Survival Following Live Kidney Donation. JAMA, 2010; 303 (10): 959-966 [link]

Cite This Page:

JAMA and Archives Journals. "Donating kidney does not appear to significantly increase long-term risk of death." ScienceDaily. ScienceDaily, 15 March 2010. <www.sciencedaily.com/releases/2010/03/100309161830.htm>.
JAMA and Archives Journals. (2010, March 15). Donating kidney does not appear to significantly increase long-term risk of death. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2010/03/100309161830.htm
JAMA and Archives Journals. "Donating kidney does not appear to significantly increase long-term risk of death." ScienceDaily. www.sciencedaily.com/releases/2010/03/100309161830.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins