Featured Research

from universities, journals, and other organizations

Gastric bypass surgery increases risk of kidney stones, study suggests

Date:
March 11, 2010
Source:
UT Southwestern Medical Center
Summary:
Patients who undergo gastric bypass surgery experience changes in their urine composition that increase their risk of developing kidney stones, research suggests.

Patients who undergo gastric bypass surgery experience changes in their urine composition that increase their risk of developing kidney stones, research from UT Southwestern Medical Center investigators suggests.

A new study, published in the March issue of The Journal of Urology, found that some of these urinary changes place weight-loss surgery patients at higher risk for developing kidney stones than obese patients who do not undergo the procedure.

For the study, researchers collected urine samples from 38 study participants. There were 16 women and three men in each of two groups. One group had undergone Roux-en-Y gastric bypass (RYGB) surgery; the second group contained normal obese individuals. RYGB, which is one of the most commonly performed weight-loss procedures, involves the creation of a small gastric pouch and allows food to bypass part of the small intestine.

The researchers found that the excretion of a material called oxalate in urine was significantly greater in the participants who had the surgical procedure than those who did not (47 percent, compared with 10.5 percent, respectively). In addition, the amount of a chemical called citrate in the urine was low in many gastric bypass patients in comparison to the obese nonsurgical group (32 percent to 5 percent).

Oxalate is found in the majority of kidney stones, while citrate inhibits stone formation.

"Almost half of the patients who had undergone gastric bypass and did not have a history of kidney stones showed high urine oxalate and low urine citrate -- factors that lead to kidney-stone formation," said Dr. Naim Maalouf, assistant professor of internal medicine in the Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and the study's lead author.

The cause for stone formation after bariatric surgery is not entirely clear, but the study reinforces the message that weight-loss surgery patients and their physicians should be alert to the heightened risk, Dr. Maalouf said.

"These findings illustrate that the majority of patients are at risk for kidney-stone formation after RYGB," Dr. Maalouf said. "This complication may not be well-recognized in part because it tends to occur months to years after the bypass surgery."

Other UT Southwestern researchers involved in the study were Dr. Eve Guth, assistant professor of internal medicine; Dr. Edward Livingston, chief of GI/endocrine surgery; and Dr. Khashayar Sakhaee, chief of mineral metabolism and the study's senior author.

The research was supported by the National Institutes of Health.


Story Source:

The above story is based on materials provided by UT Southwestern Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Naim M. Maalouf, Prasanthi Tondapu, Eve S. Guth, Edward H. Livingston, Khashayar Sakhaee. Hypocitraturia and Hyperoxaluria After Roux-en-Y Gastric Bypass Surgery. Journal of Urology, 2010; 183 (3): 1026-1030) DOI: 10.1016/j.juro.2009.11.022

Cite This Page:

UT Southwestern Medical Center. "Gastric bypass surgery increases risk of kidney stones, study suggests." ScienceDaily. ScienceDaily, 11 March 2010. <www.sciencedaily.com/releases/2010/03/100310175143.htm>.
UT Southwestern Medical Center. (2010, March 11). Gastric bypass surgery increases risk of kidney stones, study suggests. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2010/03/100310175143.htm
UT Southwestern Medical Center. "Gastric bypass surgery increases risk of kidney stones, study suggests." ScienceDaily. www.sciencedaily.com/releases/2010/03/100310175143.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins