Featured Research

from universities, journals, and other organizations

Effects of lifestyle and exposures are mirrored in blood gene expression

Date:
March 13, 2010
Source:
Public Library of Science
Summary:
A study by Norwegian and French researchers hopes to provide new understanding of how blood cells adjust gene expression in response to various clinical, biochemical and pathological conditions. The Norwegian Woman and Cancer postgenome study highlights numerous blood gene sets affected by one's physical condition, lifestyle factors and exposure variables.

A study by Norwegian and French researchers hopes to provide new understanding of how blood cells adjust gene expression in response to various clinical, biochemical and pathological conditions. The Norwegian Woman and Cancer (NOWAC) postgenome study, published March 12 in the open-access journal PLoS Genetics, highlights numerous blood gene sets affected by one's physical condition, lifestyle factors and exposure variables.

The authors used 286 blood samples from postmenopausal Norwegian women, collected from the NOWAC postgenome biobank and processed via both a standardized blood collection procedure and an experimentally-validated microarray platform. Using these samples, the researchers investigated blood gene expression changes due to technical variability (e.g., how samples were collected, transported, and stored), normal inter-individuality (e.g., body mass index), and exposure variables (e.g., smoking, hormone therapy, and medication use), at levels relevant to real life situations. They established that these effects are mirrored in the blood.

Although blood gene expression profiling promises molecular-level insight into disease mechanisms, there remains a lack of baseline data describing the nature and extent of variability in blood gene expression in the general population. Characterizations of this variation and the underlying factors that most influence gene expression among healthy individuals play an important role in the feasibility, design and analysis of future blood-based studies investigating biomarkers for exposure, disease progression, diagnosis or prognosis.

The authors conclude that their findings establish the feasibility of blood gene expression profiling to detect exposure-specific differences in the general population, and that failure to consider this type of technical or biological variation can result in the misidentification of genes when investigating predictive, diagnostic or prognostic signatures in blood.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Dumeaux V, Olsen KS, Nuel G, Paulssen RH, Bψrresen-Dale A-L, et al. Deciphering Normal Blood Gene Expression Variation -- The NOWAC Postgenome Study. PLoS Genetics, 2010; 6 (3): e1000873 DOI: 10.1371/journal.pgen.1000873

Cite This Page:

Public Library of Science. "Effects of lifestyle and exposures are mirrored in blood gene expression." ScienceDaily. ScienceDaily, 13 March 2010. <www.sciencedaily.com/releases/2010/03/100311202723.htm>.
Public Library of Science. (2010, March 13). Effects of lifestyle and exposures are mirrored in blood gene expression. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2010/03/100311202723.htm
Public Library of Science. "Effects of lifestyle and exposures are mirrored in blood gene expression." ScienceDaily. www.sciencedaily.com/releases/2010/03/100311202723.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) — The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) — Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) — New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) — Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins