Featured Research

from universities, journals, and other organizations

Living longer: Colon cancer patients gain time with radiofrequency ablation treatment

Date:
March 30, 2010
Source:
Society of Interventional Radiology
Summary:
Approximately half of Americans living with colorectal cancer will develop liver metastases at some point during the course of their disease. Radiofrequency ablation, a minimally invasive treatment that applies heat directly in the tumor causing cancer cell death with minimal associated injury to the surrounding healthy liver, contributes to prolongation of their life by nearly three years, note researchers.

Approximately half of Americans living with colorectal cancer will develop liver metastases at some point during the course of their disease. Radiofrequency ablation, a minimally invasive treatment that applies heat directly in the tumor causing cancer cell death with minimal associated injury to the surrounding healthy liver, contributes to prolongation of their life by nearly three years, note researchers at the Society of Interventional Radiology's 35th Annual Scientific Meeting in Tampa, Fla.

"Patients who have recurrent colon cancer in their liver after surgery can be treated with radiofrequency ablation, or RFA, and avoid repeated liver surgery," said Constantinos T. Sofocleous, M.D., Ph.D., FSIR, an interventional radiologist at Memorial Sloan-Kettering Cancer Center in New York, N.Y. "RFA kills target cancer tissue with heat, while sparing the healthy tissue. This is particularly important for patients who develop new colon cancer in the liver after prior surgery. In general, these patients have a smaller amount of liver tissue; another surgery is usually not possible or very difficult and associated with higher risk," added Sofocleous, an associate professor of radiology at Weill Cornell Medical College, New York, N.Y. "This research shows how interventional radiologists can treat patients who have failed a prior surgical treatment. In addition it demonstrates how the combination of all available treatment modalities and the cooperation of medical specialists can improve the outcomes and may prolong patients' lives," he explained.

Colon cancer is the second leading cause of cancer-related death in the United States, with almost 150,000 new patients diagnosed each year, said Sofocleous. Approximately half of these patients will develop liver metastases at some point during the course of their disease; the majority of the patients are not candidates for surgery. "In those who undergo surgery, recurrence is a serious problem. Traditionally chemotherapy has been the only therapy. Radiofrequency ablation is a treatment that can destroy the tumor locally in the liver and -- in combination with systemic and local hepatic arterial chemotherapy -- it may extend the life of selected patients," he added.

"While the study did not make any direct comparisons to other treatments, survival rates after RFA were comparable to those of surgery," said Sofocleous. "We treated 56 patients -- a highly selective population who had multiple prior treatments with surgery, systemic and local chemotherapy -- using computed tomography- (CT) guided RFA -- over a six-year period and had survival rates of 91 percent at one year, 66 percent at two years and 41 percent at three years," said Sofocleous. More importantly, these survival rates -- or life extensions -- are in addition to the patients' survival rates after surgery," added the co-author of "Radiofrequency Ablation of Recurrent Colorectal Cancer Hepatic Metastases After Hepatectomy."

Radiofrequency ablation can be performed without affecting a patient's overall health, and most people can be discharged from the hospital within 24 hours and resume their usual activities in a few days. In this treatment, an interventional radiologist uses imaging to guide a needle through the skin into the tumor. The needle deposits radiofrequency energy into the target tissue, where it produces heat and kills the cancerous cells, sparing healthy tissue.

Medical records and relevant imaging were reviewed to determine technical success, complications and local tumor progression. Average tumor size was 1.9 centimeters, with average overall survival rate being 31 months. A modified clinical risk score was used to analyze the correlation with survival and local tumor progression according to nodal status of the primary cancer, interval from primary to liver metastases, number of tumors and size of the largest tumor ablated. Patients and tumor characteristics with having two or less of these risks factors had the best outcomes. Researchers also evaluated the influence of hepatic artery infusion (pump) chemotherapy on local disease and overall survival.


Story Source:

The above story is based on materials provided by Society of Interventional Radiology. Note: Materials may be edited for content and length.


Cite This Page:

Society of Interventional Radiology. "Living longer: Colon cancer patients gain time with radiofrequency ablation treatment." ScienceDaily. ScienceDaily, 30 March 2010. <www.sciencedaily.com/releases/2010/03/100316101354.htm>.
Society of Interventional Radiology. (2010, March 30). Living longer: Colon cancer patients gain time with radiofrequency ablation treatment. ScienceDaily. Retrieved July 26, 2014 from www.sciencedaily.com/releases/2010/03/100316101354.htm
Society of Interventional Radiology. "Living longer: Colon cancer patients gain time with radiofrequency ablation treatment." ScienceDaily. www.sciencedaily.com/releases/2010/03/100316101354.htm (accessed July 26, 2014).

Share This




More Health & Medicine News

Saturday, July 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins