Featured Research

from universities, journals, and other organizations

Virtual biopsy probe system is 'almost perfect' in detecting precancerous polyps during colonoscopy

Date:
March 26, 2010
Source:
Mayo Clinic
Summary:
The newest generation of "virtual biopsy" colonoscopy probes being tested demonstrate that it might soon be possible to use such a device to determine whether a colon polyp is benign and not remove it for biopsy. Currently, all colon polyps are extracted during a colonoscopy and sent to a pathologist for examination, which adds time, expense, and some surgical risk, to the procedure.

The newest generation of "virtual biopsy" colonoscopy probes being tested at the Mayo Clinic campus in Florida demonstrate that it might soon be possible to use such a device to determine whether a colon polyp is benign and not remove it for biopsy. Currently, all colon polyps are extracted during a colonoscopy and sent to a pathologist for examination, which adds time, expense, and some surgical risk, to the procedure.

In the March issue of Gastroenterology, the researchers report that the most advanced of these two devices, the probe-based Confocal Laser Endomicroscopy (pCLE), is much more accurate than virtual chromoendoscopy, also known as narrow-band imaging. The pCLE -- an imaging tool only one-sixteenth of an inch in diameter -- can magnify a polyp by a factor of 1,000 to detect potentially dangerous changes in even single cells, such as enlargement of the nuclei. Narrow-band imaging uses blue light to enhance an image.

The researchers found that pCLE was 91 percent accurate in detecting precancerous polyps and narrow-band imaging was 77 percent accurate, when compared to biopsy findings..

"We are getting closer to where we want to be, which is 100 percent accurate," says the study's senior author, Michael Wallace, M.D., M.P.H., professor of medicine at the College of Medicine, Mayo Clinic, in Florida. "Some day soon we will be able to use these probes to virtually biopsy a polyp, removing only those that could become cancerous."

Half of all polyps now removed during a colonoscopy are benign, Dr. Wallace says.

Both methods tested by Dr. Wallace and his team are being used in some institutions such as Mayo Clinic to look at the area where a polyp has just been removed to make sure no precancerous cells remain at the surgical edges. That can be determined by looking at changes in cell color and size, how nuclei look, and whether cells are crowded together due to abnormal growth.

In this study, researchers administered a standard colonoscopy to 75 patients, and during the procedure used narrow-band imaging as well as pCLE to determine cancer risk in the polyps. In all, 119 polyps were removed from the patients and sent to pathologists for analysis. Eighty-one polyps were precancerous and 38 were benign. Both methods were equally specific, meaning that they had the same ability to detect benign polyps, but the pCLE system was much more sensitive in detecting precancerous polyps.

Dr. Wallace continues to test the pCLE system in colonoscopy, and is also researching its use in inflammatory bowel disease and Barrett's esophagus. Patients with inflammatory bowel disease require frequent biopsies of their colon to screen for development of colon cancer, and the probe may be able to eliminate many of these biopsies, he says. "A patient with this condition usually needs 42 biopsies of their colon during a single examination, but only 1 in every 1,000 biopsies ever show precancerous changes," he says. "We have a clinical trial under way using pCLE that suggests we may be able to substantially reduce the need for these biopsies."

Similarly, Dr. Wallace's data shows that the probe system could reduce biopsies in Barrett's esophagus, a potentially precancerous condition in which the tissue lining the esophagus is replaced by tissue that is similar to the lining of the intestine. To rule out cancer development, physicians normally biopsy every four inches of the esophagus in patients who have Barrett's esophagus. "We believe the probe system will perform virtual biopsies that are just as valuable," Dr. Wallace says.

The study was funded by an American Society of Gastrointestinal Endoscopy Research Award. Dr. Wallace receives research grant support from Mauna Kea Technologies.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Virtual biopsy probe system is 'almost perfect' in detecting precancerous polyps during colonoscopy." ScienceDaily. ScienceDaily, 26 March 2010. <www.sciencedaily.com/releases/2010/03/100323111601.htm>.
Mayo Clinic. (2010, March 26). Virtual biopsy probe system is 'almost perfect' in detecting precancerous polyps during colonoscopy. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2010/03/100323111601.htm
Mayo Clinic. "Virtual biopsy probe system is 'almost perfect' in detecting precancerous polyps during colonoscopy." ScienceDaily. www.sciencedaily.com/releases/2010/03/100323111601.htm (accessed August 22, 2014).

Share This




More Health & Medicine News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins