Featured Research

from universities, journals, and other organizations

How immune cells 'sniff out' bacteria

Date:
April 9, 2010
Source:
Society for General Microbiology
Summary:
Scientists are learning how our immune system senses and tracks down infection in the body by responding to chemical "scents" emitted by bacteria. Studying how immune cells manipulate their movement in response to external signals could shed light not only on how our immune system functions but also how cancer cells spread through the body and even how the brain wires itself.

Biophysicists at Yale created a method to stimulate single living cells with light and microparticles. Left side: The five particles pictured are trapped with laser tweezers and release a chemical which attracts the cell. Right side: The cell encounters a larger chemical concentration close to the particles (white-yellow region) than further away from the particles (red-black region).
Credit: Holger Kress and Eric Dufresne

Scientists are learning how our immune system senses and tracks down infection in the body by responding to chemical "scents" emitted by bacteria. Studying how immune cells manipulate their movement in response to external signals could shed light not only on how our immune system functions but also how cancer cells spread through the body and even how the brain wires itself.

Related Articles


Speaking at the Society for General Microbiology's spring meeting in Edinburgh, Dr Holger Kress described a new technique pioneered by himself and Professor Eric Dufresne at Yale University in the US that uses sponge-like micro-particles to mimic bacteria.

The micro-particles slowly release a characteristic bacterial "scent" that is picked up by immune cells, causing them to actively move towards the source of the chemical in an attempt to hunt down the model microbes. These micro-particles can be trapped and manipulated three-dimensionally using 'optical tweezers' -- highly focussed laser beams that are able to precisely control the movement of the particles to within a millionth of a millimetre. "By controlling the shape of the chemical signals, we were able to control the movements of immune cells and study how they respond to the signals," said Dr Kress.

The scientists found that a single chemical-releasing micro-particle was enough to encourage neutrophils (a type of immune cell) to migrate towards it. Within less than one minute's exposure to the micro-particle, the neutrophils were able to polarize the growth of their internal 'skeleton' in the direction of the chemical.

Dr Kress explained that although researchers had successfully identified the types of chemical signals that stimulate immune cells, it is still a challenge to work out the exact details of the immune cell response. "This new technique allows us to measure systematically how cells respond to various stimuli over minute gradients in time and space."

Dr Kress believes his technique could be applied across a wide range of research fields. "Cell migration along chemical gradients of this kind plays a key role in wound healing and the wiring of the brain. It is also an essential feature of many diseases -- particularly metastatic cancers," he said.


Story Source:

The above story is based on materials provided by Society for General Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

Society for General Microbiology. "How immune cells 'sniff out' bacteria." ScienceDaily. ScienceDaily, 9 April 2010. <www.sciencedaily.com/releases/2010/03/100329203222.htm>.
Society for General Microbiology. (2010, April 9). How immune cells 'sniff out' bacteria. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2010/03/100329203222.htm
Society for General Microbiology. "How immune cells 'sniff out' bacteria." ScienceDaily. www.sciencedaily.com/releases/2010/03/100329203222.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) — Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins