Featured Research

from universities, journals, and other organizations

Scientists find therapeutic target to stop cancer metastases

Date:
April 1, 2010
Source:
Federation of American Societies for Experimental Biology
Summary:
Scientists have uncovered what could be a very important clue in answering one of the most perplexing questions about cancer: why does it spread to the liver more than any other organ? In a new research report, scientists from New York University describe experimental results suggesting that the immune system may be the reason.

Scientists have uncovered what could be a very important clue in answering one of the most perplexing questions about cancer: why does it spread to the liver more than any other organ? In a new research report published in the April 2010 issue of Journal of Leukocyte Biology, scientists from New York University describe experimental results suggesting that the immune system may be the reason.

"Our work may open a new field of experimental therapeutics as combating the eventual development of liver metastases by targeting immune suppressive cells in the livers in patients with early cancer can have great benefit," said George Miller, a scientist involved in the work from the Departments of Surgery and Cell Biology at the New York University School of Medicine.

Miller and colleagues reached this conclusion after conducting experiments in mice. In the experiments, the researchers used mice that spontaneously developed pancreatic cancer because of a mutation (Kras-mutation) in the progenitor cells of the pancreas, as well as mice with advanced colon cancers that spread to the abdomen. They then studied the expansion of immune suppressive cells in the liver from a very early stage in the cancer development to determine the immune phenotype, stimulus for recruitment, inhibitory effects and tumor-enabling function of these cells. Results suggest that combating immune suppressive cells in the liver early after cancer development may prevent the spread of cancer to this vital organ.

"This study could represent one of those 'a-ha' moments in science where one idea or experiment opens up entirely new ways of approaching and understanding a problem," said Luis Montaner, Editor-in-Chief of the Journal of Leukocyte Biology. "Physicians have known that the spread of cancer to the liver is far too common to occur by chance. Now we know that the immune system likely plays a role in facilitating this process. The next step, obviously, is to learn more so we can prevent it from happening."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. K. Connolly, J. M. St. Clair, A. S. Bedrosian, A. Malhotra, V. Vera, J. Ibrahim, J. Henning, H. L. Pachter, D. Bar-Sagi, A. B. Frey, G. Miller. Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor. Journal of Leukocyte Biology, 2009; DOI: 10.1189/jlb.0909607

Cite This Page:

Federation of American Societies for Experimental Biology. "Scientists find therapeutic target to stop cancer metastases." ScienceDaily. ScienceDaily, 1 April 2010. <www.sciencedaily.com/releases/2010/03/100331104919.htm>.
Federation of American Societies for Experimental Biology. (2010, April 1). Scientists find therapeutic target to stop cancer metastases. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2010/03/100331104919.htm
Federation of American Societies for Experimental Biology. "Scientists find therapeutic target to stop cancer metastases." ScienceDaily. www.sciencedaily.com/releases/2010/03/100331104919.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com
Michigan Man Sees Thanks to 'bionic Eye'

Michigan Man Sees Thanks to 'bionic Eye'

AP (Apr. 23, 2014) A legally blind Michigan man is 'seeing something new every day' thanks to a high-tech retinal implant procedure. He's one of the first in the country to receive a 'bionic eye' since the federal government approved the surgery. (April 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins