Featured Research

from universities, journals, and other organizations

Treat acne with coconut oil and nano-bombs

Date:
April 15, 2010
Source:
University of California - San Diego
Summary:
A natural product found in both coconut oil and human breast milk -- lauric acid -- shines as a possible new acne treatment, thanks to a bioengineering graduate student. The student developed a "smart delivery system" capable of delivering lauric-acid-filled nano-scale bombs directly to skin-dwelling bacteria (Propionibacterium acnes) that cause common acne.

Ph.D. student Dissaya “Nu” Pornpattananangkul is developing a smart system of drug delivery.
Credit: Image courtesy of University of California - San Diego

A natural product found in both coconut oil and human breast milk -- lauric acid -- shines as a possible new acne treatment thanks to a bioengineering graduate student from the UC San Diego Jacobs School of Engineering.

The student developed a "smart delivery system" -- published in the journal ACS Nano in March -- capable of delivering lauric-acid-filled nano-scale bombs directly to skin-dwelling bacteria (Propionibacterium acnes) that cause common acne.

On Thursday April 15, bioengineering graduate student Dissaya "Nu" Pornpattananangkul will present her most recent work on this experimental acne-drug-delivery system at Research Expo, the annual research conference of the UC San Diego Jacobs School of Engineering.

Common acne, also known as "acne vulgaris," afflicts more than 85 percent of teenagers and over 40 million people in the United States; and current treatments have undesirable side effects including redness and burning. Lauric-acid-based treatments could avoid these side effects, the UC San Diego researchers say.

"It's a good feeling to know that I have a chance to develop a drug that could help people with acne," said Pornpattananangkul, who performs this research in the Nanomaterials and Nanomedicine Laboratory of UC San Diego NanoEngineering professor Liangfang Zhang from the Jacobs School of Engineering.

The new smart delivery system includes gold nanoparticles attached to surfaces of lauric-acid-filled nano-bombs. The gold nanoparticles keep the nano-bombs (liposomes) from fusing together. The gold nanoparticles also help the liposomes locate acne-causing bacteria based on the skin microenvironment, including pH.

Once the nano-bombs reach the bacterial membranes, the acidic microenvironment causes the gold nanoparticles to drop off. This frees the liposomes carrying lauric acid payloads to fuse with bacterial membranes and kill the Propionibacterium acnes bacteria.

"Precisely controlled nano-scale delivery of drugs that are applied topically to the skin could significantly improve the treatment of skin bacterial infections. By delivering drugs directly to the bacteria of interest, we hope to boost antimicrobial efficacy and minimize off-target adverse effects," said Zhang. "All building blocks of the nano-bombs are either natural products or have been approved for clinical use, which means these nano-bombs are likely to be tested on humans in the near future."

Zhang noted that nano-scale topical drug delivery systems face a different set of challenges than systems that use nanotechnology to deliver drugs systematically to people.

Pornpattananangkul and UC San Diego chemical engineering undergraduate Darren Yang confirmed, in 2009 in the journal Biomaterials, the antimicrobial activity of nano-scale packets of lauric acid against Propionibacterium acnes.

Pornpattananangkul, who is originally from Thailand, said that it's just a coincidence that her research involves a natural product produced by coconuts -- a staple of Thai cuisine.


Story Source:

The above story is based on materials provided by University of California - San Diego. Note: Materials may be edited for content and length.


Journal Reference:

  1. Dissaya Pornpattananangkul, Sage Olson, Santosh Aryal, Marta Sartor, Chun-Ming Huang, Kenneth Vecchio, Liangfang Zhang. Stimuli-Responsive Liposome Fusion Mediated by Gold Nanoparticles. ACS Nano, 2010: 100317124523087 DOI: 10.1021/nn9018587

Cite This Page:

University of California - San Diego. "Treat acne with coconut oil and nano-bombs." ScienceDaily. ScienceDaily, 15 April 2010. <www.sciencedaily.com/releases/2010/04/100414184224.htm>.
University of California - San Diego. (2010, April 15). Treat acne with coconut oil and nano-bombs. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2010/04/100414184224.htm
University of California - San Diego. "Treat acne with coconut oil and nano-bombs." ScienceDaily. www.sciencedaily.com/releases/2010/04/100414184224.htm (accessed April 24, 2014).

Share This



More Matter & Energy News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Obama Plays Soccer With Japanese Robot

Raw: Obama Plays Soccer With Japanese Robot

AP (Apr. 24, 2014) President Obama briefly played soccer with a robot during his visit to Japan on Thursday. The President has been emphasizing technology along with security concerns during his visit. (April 24) Video provided by AP
Powered by NewsLook.com
Obama Encourages Japanese Student-Scientists

Obama Encourages Japanese Student-Scientists

AP (Apr. 24, 2014) President Obama spoke with student innovators in Japan and urged them to take part in increased opportunities for student exchanges with the US. (April 24) Video provided by AP
Powered by NewsLook.com
UN Joint Mission Starts Removing Landmines in Cyprus

UN Joint Mission Starts Removing Landmines in Cyprus

AFP (Apr. 23, 2014) The UN mission in Cyprus (UNFICYP) led a mine clearance demonstration on Wednesday in the UN-controlled buffer zone where demining operations are being conducted near the Cypriot village of Mammari. Duration: 01:00 Video provided by AFP
Powered by NewsLook.com
Air Force: $4.2B Saved from Grounding A-10s

Air Force: $4.2B Saved from Grounding A-10s

AP (Apr. 23, 2014) Speaking about the future of the United States Air Force, Chief of Staff Gen. Mark Welsh says the choice to divest the A-10 fleet was logical and least impactful. (April 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins