Featured Research

from universities, journals, and other organizations

Uncovering early stages of Alzheimer's disease

Date:
April 18, 2010
Source:
CSIRO Australia
Summary:
A major Australian study has provided new insights into the loss of structure in regions of the brain and its potential association with Alzheimer's disease.

In vivo imaging of amyloid-beta plaques and brain atrophy of a healthy elderly person (left) compared to an Alzheimer's disease patient (right).
Credit: CSIRO

A major Australian study has provided new insights into the loss of structure in regions of the brain and its potential association with Alzheimer's Disease.

Related Articles


The findings recently reported in Neurology suggest a build-up of deposits of the protein amyloid-beta in a region of the brain known as the temporal inferior cortex. The region is connected to the hippocampus, which is involved in memory.

Alzheimer's is characterised by two factors: a build-up of amyloid-beta plaques in the brain, and a loss of neurons.

CSIRO's Preventative Health Flagship Theme Leader, Dr Cassandra Szoeke, said the puzzle for researchers was that the parts of the brain that had shrunk (atrophied) due to neuron loss were not the same as those showing increased deposits of amyloid-beta.

Using MRI scans to study Alzheimer's disease-affected brain tissue, the researchers found that shrinking (atrophy) of the hippocampus was associated with plaque deposits in the temporal inferior cortex.

The results indicate that the increased accumulation of amyloid in the temporal inferior cortex disrupts connections with the hippocampus, causing the neurons to die.

"By helping to better understand the mechanisms involved in the progression of the disease, the study may guide the development of new strategies for early diagnosis," Dr Szoeke said.

The study involved advanced techniques for analysing and comparing different types of brain scans. Lead researcher was Dr Perrick Bourgeat, from the Australian e-Health Research Centre -- a joint venture between CSIRO and the Queensland Government.

The research was conducted under the umbrella of the P-Health Flagship's Collaboration Fund Cluster. The Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) Study is being undertaken by CSIRO, the University of Melbourne, Edith Cowan University, Neurosciences Australia and the Mental Health Institute of Victoria.


Story Source:

The above story is based on materials provided by CSIRO Australia. Note: Materials may be edited for content and length.


Journal Reference:

  1. P. Bourgeat, G. Chιtelat, V. L. Villemagne, J. Fripp, P. Raniga, K. Pike, O. Acosta, C. Szoeke, S. Ourselin, D. Ames, K. A. Ellis, R. N. Martins, C. L. Masters, C. C. Rowe, O. Salvado, and On behalf of the AIBL Research Group. β-Amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia. Neurology, 2010; 74: 121-127 [link]

Cite This Page:

CSIRO Australia. "Uncovering early stages of Alzheimer's disease." ScienceDaily. ScienceDaily, 18 April 2010. <www.sciencedaily.com/releases/2010/04/100416095806.htm>.
CSIRO Australia. (2010, April 18). Uncovering early stages of Alzheimer's disease. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2010/04/100416095806.htm
CSIRO Australia. "Uncovering early stages of Alzheimer's disease." ScienceDaily. www.sciencedaily.com/releases/2010/04/100416095806.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) — The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
Study Shows Newborn Chicks Count From Left to Right Just Like Humans

Study Shows Newborn Chicks Count From Left to Right Just Like Humans

Buzz60 (Jan. 30, 2015) — Researchers for the first time identified human&apos;s innate preference for associating low and high numbers with the left and right respectively in another species. Jen Markham (@jenmarkham) explains. Video provided by Buzz60
Powered by NewsLook.com
Best Mood Elevating, Feel Good Shakes & Smoothies

Best Mood Elevating, Feel Good Shakes & Smoothies

Buzz60 (Jan. 30, 2015) — You can elevate your mood by having a meal in a glass. Fitness and nutrition expert John Basedow (@JohnBasedow) offers the best &apos;feel good&apos; smoothies and shakes chock full of depression-relieving ingredients...including apples, berries, lemons, cucumbers, papaya, kiwi, spinach, kale, whey protein, matcha, ginger, turmeric and cinnamon. Video provided by Buzz60
Powered by NewsLook.com
Poll Says Firstborn Is Responsible, Youngest Is Funnier

Poll Says Firstborn Is Responsible, Youngest Is Funnier

Newsy (Jan. 30, 2015) — According to a poll out of the U.K., eldest siblings feel more responsible and successful than their younger siblings. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins