Featured Research

from universities, journals, and other organizations

Ischemic preconditioning alters hepatic blood supply

Date:
April 19, 2010
Source:
World Journal of Gastroenterology
Summary:
A research team from Switzerland and Germany investigated some underlying protective mechanisms of ischemic preconditioning (IP) and found that IP leads to a better blood supply to the liver, which then was associated with reduced hepatocellular damage and less complications following hepatectomies.

Liver surgery has become a safe procedure in the past years and is mainly done because of malignant tumors. A common strategy to reduce blood loss during surgery is to temporarily shut down the blood supply to the liver [pringle maneuver (PM)], which, however may be associated with severe hepatocellular injury and consequent enhanced morbidity.

Many efforts were undertaken to overcome the deleterious effects of ischemia-reperfusion (I/R) injury of the liver caused by the PM. A new method of hepatocellular protection comprises ischemic preconditioning (IP), i.e. an additional short ischemia and reperfusion period prior to sustained ischemia, as set by the PM. However, mechanisms of protection by IP are still largely unknown. Also, no data were available which comment on hepatic macroperfusion under different conditions, such as IP.

A research article to be published on April 21, 2010 in the World Journal of Gastroenterology addresses this question. The research team from Switzerland and Germany investigated whether IP may also improve the blood flow in the hepatic artery (HA) and the portal vein (PV), i.e., the macrocirculation during liver resections in humans.

In this randomized study, the researchers could demonstrate a significant impact of IP on the blood flows of HA and PV when compared to a control group subjected to liver resection with the PM, but without IP. For the first time the authors could show in a human study that IP significantly enhanced the arterial blood flow on reperfusion of ischemic livers whereas the portal blood flow remained unaffected in this group. When compared to liver resections without IP (PM only), the total blood flow was markedly increased by IP, in particular because a severe decrease in the PV perfusion was not adequately compensated by the HA blood flow in the control group.

Furthermore, an inverse correlation between the HA flow and the amount of hepatocellular damage could be demonstrated, suggesting the quality of HA perfusion was a distinct prerequisite for the maintenance of liver function during ischemia and reperfusion.

Because PV flows showed no correlation with hepatocellular injury, the authors suggest that during liver surgery temporary occlusion of the portal vein, but not of the hepatic artery (partial PM) may help to avoid I/R-related complications in liver surgery. In further studies, the impact of macrohemodynamic changes on the hepatic microcirculation should be elucidated because, at this time, no data are available concerning this important issue.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Heizmann O, Meimarakis G, Volk A, Matz D, Oertli D, Schauer RJ. Ischemic preconditioning-induced hyperperfusion correlates with hepatoprotection after liver resection. World Journal of Gastroenterology, 2010; 16 (15): 1871 DOI: 10.3748/wjg.v16.i15.1871

Cite This Page:

World Journal of Gastroenterology. "Ischemic preconditioning alters hepatic blood supply." ScienceDaily. ScienceDaily, 19 April 2010. <www.sciencedaily.com/releases/2010/04/100419102425.htm>.
World Journal of Gastroenterology. (2010, April 19). Ischemic preconditioning alters hepatic blood supply. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2010/04/100419102425.htm
World Journal of Gastroenterology. "Ischemic preconditioning alters hepatic blood supply." ScienceDaily. www.sciencedaily.com/releases/2010/04/100419102425.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins