Featured Research

from universities, journals, and other organizations

First-in-class drug tested in patients with advanced cancer; targets stem-like properties of certain cancer cells

Date:
April 21, 2010
Source:
American Association for Cancer Research
Summary:
Researchers are working to develop a novel first-in-class cancer drug that works by targeting the stem-like properties of some cancer cells, and so far, results of an ongoing Phase I clinical trial demonstrate early signs of a strong safety profile and clinical activity.

Researchers at Boston Biomedical, Inc., are working to develop a novel first-in-class cancer drug that works by targeting the stem like properties of some cancer cells, and so far, results of an ongoing Phase I clinical trial demonstrate early signs of a strong safety profile and clinical activity.

"Cancer stem cells arguably represent one of the hottest frontiers in cancer research today," said Chiang J. Li, M.D., chairman and chief executive officer of Boston Biomedical, Inc., Norwood, Mass., who led the research discovery. "If the cancer stem cell hypothesis is proven to be correct, it should be possible to fundamentally advance treatment for patients with a wide variety of cancers because these highly malignant cell populations are inherently resistant to conventional therapies."

Updated data will be presented during the late-breaking clinical trial symposium at the AACR 101st Annual Meeting 2010, held April 17-21.

Li and colleagues took an unconventional line of attack by developing BBI608, a first-in-class cancer cell stemness inhibitor that can target highly malignant cancer stem cells as well as other heterogenous cancer cells.

"Current debates or controversies regarding the cancer stem cell hypothesis are less relevant to our approach since we believe it is crucial to target all malignant cells," said Li.

The Phase I study of BBI608 was designed to determine its safety and to establish a dose regimen for Phase II trials in adult patients with various advanced cancers. The study is being conducted at the Segal Cancer Center, Montreal, Quebec, Canada; the Juravinski Cancer Center, Hamilton, Ontario, Canada; and the Karmanos Cancer Center, Detroit, Mich.

As of March 26, 2010, 18 cancer patients with various solid tumors were enrolled in the study.

Treatment with BBI608 consisted of twice-daily, oral administration for four-week cycles. Dose escalation of BBI608 has reached a daily regimen of 600 mg, and the blood concentration of BBI608 has exceeded the level required to kill cancer stem cells and heterogeneous cancer cells in the laboratory.

Patients have tolerated the escalating doses of BBI608 very well with no significant drug-related side effects. To date, nine patients were evaluated for antitumor activity, of which six have achieved stable disease for at least two months with early signs of tumor regression and prolonged stable disease.

"We are encouraged by the early clinical data which supports our further efforts targeting cancer cell stemness," Li said. "Through incredible team effort and hard work we have accomplished the discovery of BBI608, and its translation from bench to bedside in less than 24 months, which, to our knowledge, sets a record pace for translational medicine. We are very excited about our novel approach and the therapeutic potential of cancer cell stemness inhibitors."


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "First-in-class drug tested in patients with advanced cancer; targets stem-like properties of certain cancer cells." ScienceDaily. ScienceDaily, 21 April 2010. <www.sciencedaily.com/releases/2010/04/100419162117.htm>.
American Association for Cancer Research. (2010, April 21). First-in-class drug tested in patients with advanced cancer; targets stem-like properties of certain cancer cells. ScienceDaily. Retrieved August 2, 2014 from www.sciencedaily.com/releases/2010/04/100419162117.htm
American Association for Cancer Research. "First-in-class drug tested in patients with advanced cancer; targets stem-like properties of certain cancer cells." ScienceDaily. www.sciencedaily.com/releases/2010/04/100419162117.htm (accessed August 2, 2014).

Share This




More Health & Medicine News

Saturday, August 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Quintuplets Head Home

Texas Quintuplets Head Home

Reuters - US Online Video (Aug. 1, 2014) After four months in the hospital, the first quintuplets to be born at Baylor University Medical Center head home. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Patient Coming to U.S. for Treatment

Ebola Patient Coming to U.S. for Treatment

Reuters - US Online Video (Aug. 1, 2014) A U.S. aid worker infected with Ebola while working in West Africa will be treated in a high security ward at Emory University in Atlanta. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins