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Oncology: Fanconi anemia pathway dysregulated in non-FA cancers

Date:
April 19, 2010
Source:
Journal of Clinical Investigation
Summary:
Individuals with the rare human genetic disease Fanconi anemia have an increased incidence of cancer. In many individuals, disease is caused by mutations in any one of 13 known genes (including FANCL) that generate proteins that function in one common signaling pathway that is known as the FA pathway. Whether this pathway has a role in human cancers in individuals who do not have Fanconi anemia has not been clearly determined.

Individuals with the rare human genetic disease Fanconi anemia have an increased incidence of cancer. In many individuals, disease is caused by mutations in any one of 13 known genes (including FANCL) that generate proteins that function in one common signaling pathway that is known as the FA pathway. Whether this pathway has a role in human cancers in individuals who do not have Fanconi anemia has not been clearly determined.

But now, Peiwen Fei and colleagues, at the Mayo Clinic, Rochester, have identified a new form of the protein FANCL, which they named FAVL, that dysregulates the FA pathway in non-FA human tumor cells and acts as a tumor-promoting factor.

The authors therefore conclude that impairment of the FA pathway could contribute to the development of cancer in individuals who do not have Fanconia anemia.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jun Zhang, Deping Zhao, Hwan Ki Park, Hong Wang, Roy B. Dyer, Wanguo Liu, George G. Klee, Mark A. Mcniven, Donald J. Tindall, Julian R. Molina and Peiwen Fei. FAVL elevation in human tumors disrupts Fanconi anemia pathway signaling and promotes genomic instability and tumor growth. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI40908

Cite This Page:

Journal of Clinical Investigation. "Oncology: Fanconi anemia pathway dysregulated in non-FA cancers." ScienceDaily. ScienceDaily, 19 April 2010. <www.sciencedaily.com/releases/2010/04/100419233601.htm>.
Journal of Clinical Investigation. (2010, April 19). Oncology: Fanconi anemia pathway dysregulated in non-FA cancers. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2010/04/100419233601.htm
Journal of Clinical Investigation. "Oncology: Fanconi anemia pathway dysregulated in non-FA cancers." ScienceDaily. www.sciencedaily.com/releases/2010/04/100419233601.htm (accessed August 22, 2014).

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