Featured Research

from universities, journals, and other organizations

Carbon nanotubes boost cancer-fighting cells

Date:
April 21, 2010
Source:
Yale University
Summary:
Engineers have found that the defects in carbon nanotubes cause T cell antigens to cluster in the blood and stimulate the body's natural immune response. Their findings could improve current adoptive immunotherapy, a treatment used to boost the body's ability to fight cancer.

A scanning electron microscope image shows a carbon nanotube bundle used to cluster antigens and boost T cell production.
Credit: Tarek Fahmy/Yale University

Yale University engineers have found that the defects in carbon nanotubes cause T cell antigens to cluster in the blood and stimulate the body's natural immune response. Their findings, which appear as the cover article of the April 20 issue of the journal Langmuir, could improve current adoptive immunotherapy, a treatment used to boost the body's ability to fight cancer.

Adoptive immunotherapy involves extracting a patient's blood so that the number of naturally occurring T cells (a type of white blood cell) can reproduce more effectively in the laboratory. Although the body produces its own tumor-fighting T cells, they are often suppressed by the tumor and are too few to be effective. Scientists boost the production of T cells outside the body using different substances that encourage T cell antigens to cluster in high concentrations. The better these substances are at clustering T cell antigens, the greater the immune cell proliferation. Once enough T cells are produced, the blood is transferred back into the patient's body.

The Yale team had previously reported the unexpected effect that carbon nanotubes had on T cell production. They found that the antigens, when presented on the surface of the nanotubes, stimulated T cell response far more effectively than coating other substrates such as polystyrene in the antigens, even though the total amount of antigens used remained the same.

Now they have discovered the reason behind the increased stimulation. They found that the antigens cluster in high concentrations around the tiny defects found in the carbon nanotubes.

"Carbon nanotube bundles resemble a lymph node microenvironment, which has a labyrinth sort of geometry," said Tarek Fahmy, associate professor of chemical engineering and biomedical engineering at Yale and senior author of the paper. "The nanotube bundles seem to mimic the physiology and adsorb more antigens, promoting a greater immunological response."

Current adoptive immunotherapy takes weeks to produce enough T cells, but lab tests showed that the nanotubes produced the same T cell concentration in just one-third the time, Fahmy said.

Carbon nanotubes can cause problems, such as an embolism, when used in the body. But this isn't the case when they are used in blood that has been extracted from the patient, Fahmy said. Next, the team will work on a way to effectively remove the carbon nanotubes from the blood before it is returned to the patient.

"We think this is a really interesting use of carbon nanotubes. It's a way to exploit the unique properties of this material for biological application in a safe way."

Other authors of the paper include lead author Tarek Fadel, Michael Look, Peter Staffier, Gary Haller and Lisa Pfefferle, all of the Yale School of Engineering & Applied Science.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tarek R. Fadel, Michael Look, Peter A. Staffier, Gary L. Haller, Lisa D. Pfefferle, Tarek M. Fahmy. Clustering of Stimuli on Single-Walled Carbon Nanotube Bundles Enhances Cellular Activation. Langmuir, 2010; 26 (8): 5645 DOI: 10.1021/la902068z

Cite This Page:

Yale University. "Carbon nanotubes boost cancer-fighting cells." ScienceDaily. ScienceDaily, 21 April 2010. <www.sciencedaily.com/releases/2010/04/100420132846.htm>.
Yale University. (2010, April 21). Carbon nanotubes boost cancer-fighting cells. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2010/04/100420132846.htm
Yale University. "Carbon nanotubes boost cancer-fighting cells." ScienceDaily. www.sciencedaily.com/releases/2010/04/100420132846.htm (accessed July 23, 2014).

Share This




More Matter & Energy News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Government Approves East Coast Oil Exploration

Government Approves East Coast Oil Exploration

AP (July 18, 2014) The Obama administration approved the use of sonic cannons to discover deposits under the ocean floor by shooting sound waves 100 times louder than a jet engine through waters shared by endangered whales and turtles. (July 18) Video provided by AP
Powered by NewsLook.com
Sunken German U-Boat Clearly Visible For First Time

Sunken German U-Boat Clearly Visible For First Time

Newsy (July 18, 2014) The wreckage of the German submarine U-166 has become clearly visible for the first time since it was discovered in 2001. Video provided by Newsy
Powered by NewsLook.com
Obama: U.S. Must Have "smartest Airports, Best Power Grid"

Obama: U.S. Must Have "smartest Airports, Best Power Grid"

Reuters - US Online Video (July 17, 2014) President Barak Obama stopped by at a lunch counter in Delaware before making remarks about boosting the nation's infrastructure. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Crude Oil Prices Bounce Back After Falling Below $100 a Barrel

Crude Oil Prices Bounce Back After Falling Below $100 a Barrel

TheStreet (July 16, 2014) Oil Futures are bouncing back after tumbling below $100 a barrel for the first time since May yesterday. Jeff Grossman is the president of BRG Brokerage and trades at the NYMEX. Grossman tells TheStreet the Middle East is always a concern for oil traders. Oil prices were pushed down in recent weeks on Libya increasing its production. Supply disruptions in Iraq fading also contributed to prices falling. News from China's economic front showing a growth for the second quarter also calmed fears on its slowdown. Jeff Grossman talks to TheStreet's Susannah Lee on this and more on the Energy Department's Energy Information Administration (EIA) report. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins