Featured Research

from universities, journals, and other organizations

Alcoholic cirrhosis patients had high prevalence of complications at diagnosis

Date:
April 27, 2010
Source:
Wiley - Blackwell
Summary:
A recent study by Danish researchers discovered patients with alcoholic cirrhosis had a high prevalence of complications at the time of the disease diagnosis. Researchers noted that complications, such as ascites (excessive fluid in the abdomen), were predictors of mortality, but did not develop in a predictable sequence.

A recent study by Danish researchers discovered patients with alcoholic cirrhosis had a high prevalence of complications at the time of the disease diagnosis. Researchers noted that complications, such as ascites (excessive fluid in the abdomen), were predictors of mortality, but did not develop in a predictable sequence.

Results of this 12-year mortality study appear in the May issue of Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases (AASLD).

According to a 2004 report by the World Health Organization (WHO) an estimated 2 billion people worldwide consume alcoholic beverages with 76.3 million of those having alcohol-related disorders. Alcoholic cirrhosis (scarring of the liver) is one such disease, which can occur in 10%-20% of heavy drinkers after many years of frequent drinking. In 2000 the National Institutes of Health (NIH) listed cirrhosis as the 12th leading cause of death and the 4th primary cause of mortality in individuals between 45 and 54 years of age.

The research team led by Peter Jepsen, M.D., identified potential study participants from the Danish Cause of Death Registry, the Danish National Patient Registry, or from the Danish Pathology Registry. The cohort included 466 patients whose medical records indicated cirrhosis was due in part or fully to alcohol abuse, who were diagnosed between January 1, 1993 and August 31, 2005, and who had not previously been examined for suspected cirrhosis. Participants were between the ages of 27 and 84, were 71% male and 79% consumed alcohol.

Results showed that at diagnosis of alcoholic cirrhosis, 24% of patients had no complications, 55% had ascites alone, 6% had variceal bleeding alone, 4% had ascites and variceal bleeding, and 11% had liver encephalopathy (hepatic coma). One-year mortality was 17% among patients with no initial complications, 20% following variceal bleeding alone, 29% following ascites alone, 49% following ascites and variceal bleeding (from the onset of the later of the two complications), and 64% following hepatic encephalopathy. The 5-year mortality ranged from 58% to 85%. After 1 year the risk of complications was approximately 25% and 50% after 5 years for all patients without hepatic encephalopathy.

"Our findings demonstrate that alcoholic cirrhosis patients have a high prevalence of complications at the time of their diagnosis," said Dr. Jepsen. "These complications are strong predictors of 1-year mortality, but not of the risk of developing more complications. Due to the random sequence of complication development the clinical course of alcoholic cirrhosis cannot be determined based on the presence or absence of particular cirrhosis complications," Dr. Jepsen concluded.


Story Source:

The above story is based on materials provided by Wiley - Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. Peter Jepsen, Peter Ott, Per Kragh Andersen, Henrik Toft Sψrensen, Hendrik Vilstrup. Clinical course of alcoholic liver cirrhosis: A Danish population-based cohort study. Hepatology, 2010; DOI: 10.1002/hep.23500

Cite This Page:

Wiley - Blackwell. "Alcoholic cirrhosis patients had high prevalence of complications at diagnosis." ScienceDaily. ScienceDaily, 27 April 2010. <www.sciencedaily.com/releases/2010/04/100427081047.htm>.
Wiley - Blackwell. (2010, April 27). Alcoholic cirrhosis patients had high prevalence of complications at diagnosis. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2010/04/100427081047.htm
Wiley - Blackwell. "Alcoholic cirrhosis patients had high prevalence of complications at diagnosis." ScienceDaily. www.sciencedaily.com/releases/2010/04/100427081047.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) — In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) — The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) — President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) — A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins